PPADS tetrasodium salt

Cat. No. 0625

PPADS tetrasodium salt C14H10N3Na4O12PS2 [192575-19-2]

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Chemical Name: Pyridoxalphosphate-6-azophenyl-2',4'-disulfonic acid tetrasodium salt

Biological Activity

A non-selective P2 purinergic antagonist. Blocks recombinant P2X1, P2X2, P2X3, P2X5 (IC50 = 1 - 2.6 μM), native P2Y2-like (IC50 ~ 0.9 mM), and recombinant P2Y4 (IC50 ~ 15 mM) receptors. Delays onset of calcium responses to mild hypoosmotic stress in cortical slices. iso-PPADS (Cat. No. 0683) also available.

Technical Data

M.Wt:
599.3
Formula:
C14H10N3Na4O12PS2
Solubility:
Soluble to 100 mM in water
Storage:
Desiccate at -20°C
CAS No:
192575-19-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Thrane et al (2011) Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema. Proc.Natl.Acad.Sci.U S A 108 846. PMID: 21187412.

Ralevic and Burnstock (1998) Receptors for purines and pyrimidines. Pharmacol.Rev. 50 413. PMID: 9755289.

McLaren et al (1994) Investigation of the actions of PPADS, a novel P2x-purinoceptor antagonist, in the guinea-pig isolated vas deferens. Br.J.Pharmacol. 111 913. PMID: 8019769.

Ziganshin et al (1994) Selective antagonism by PPADS at P2x-purinoceptors in rabbit isolated blood vessels. Br.J.Pharmacol. 111 923. PMID: 8019770.

Lambrecht et al (1992) PPADS, a novel functionally selective antagonist of P2 purinoceptor-mediated responses. Eur.J.Pharmacol. 217 217. PMID: 1330591.

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Citations are publications that use Tocris products. Selected citations for PPADS tetrasodium salt include:

Cheung et al (2015) Pharmacological and molecular characterization of functional P2 receptors in rat embryonic cardiomyocytes. J Mol Neurosci 11 127. PMID: 25510459.

Fonseca et al (2015) Diadenosine tetraphosphate contributes to carbachol-induced tear secretion. Purinergic Signal 11 87. PMID: 25398705.

Pozner et al (2015) Intracellular calcium dynamics in cortical microglia responding to focal laser injury in the PC::G5-tdT reporter mouse. Front Mol Neurosci 8 12. PMID: 26005403.

Bulavina et al (2013) NTPDase1 activity attenuates microglial phagocytosis. Purinergic Signal 9 199. PMID: 23208703.

Rodríguez-Zayas et al (2012) Blockade of P2 nucleotide receptors after spinal cord injury reduced the gliotic response and spared tissue. Neuropsychopharmacology 46 167. PMID: 21647706.

Kouzaki et al (2011) The danger signal, extracellular ATP, is a sensor for an airborne allergen and triggers IL-33 release and innate Th2-type responses. J Immunol 186 4375. PMID: 21357533.

Thrane et al (2011) Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema. Proc Natl Acad Sci U S A 108 846. PMID: 21187412.

Gómez-Gonzalo et al (2010) An excitatory loop with astrocytes contributes to drive neurons to seizure threshold. PLoS Biol 8 e1000352. PMID: 20405049.

Kennedy et al (2007) Identification of atropine- and P2X1 receptor antagonist-resistant, neurogenic contractions of the urinary bladder. J Neurosci 27 845. PMID: 17251425.

Zhong et al (2001) Multiple P2X receptors on guinea-pig pelvic ganglion neurons exhibit novel pharmacological properties. Br J Pharmacol 132 221. PMID: 11156581.

Gao et al (1999) Evidence that the ATP-induced increase in vasomotion of guinea-pig mesenteric lymphatics involves an endothelium-dependent release of thromboxane A2. Br J Pharmacol 127 1597. PMID: 10455315.

Liu et al (1999) Rat chromaffin cells lack P2X receptors while those of the guinea-pig express a P2X receptor with novel pharmacology. Br J Pharmacol 128 61. PMID: 10498835.

Dowd et al (1998) P2X receptor-mediated excitation of nociceptive afferents in the normal and arthritic rat knee joint. Br J Pharmacol 125 341. PMID: 9786507.

Neal et al (1998) Modulation of extracellular GABA levels in the retina by activation of glial P2X-purinoceptors. Br J Pharmacol 124 317. PMID: 9641548.

Zhong et al (1998) Pharmacological and molecular characterization of P2X receptors in rat pelvic ganglion neurons. Br J Pharmacol 125 771. PMID: 9831914.

Takata and Hirase Cortical layer 1 and layer 2/3 astrocytes exhibit distinct calcium dynamics in vivo. PLoS One 3 e2525. PMID: 18575586.

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Keywords: PPADS tetrasodium salt, supplier, P2, purinergic, antagonists, P2X, Receptors, Purinergic, P2Y, purinoceptors, Tocris Bioscience, Purinergic (P2X) Receptor Antagonist products

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