PK 11195

Cat. No. 0670

PK 11195 C21H21ClN2O [85532-75-8]

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Chemical Name: 1-(2-Chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide

Biological Activity

Possesses high affinity for the peripheral benzodiazepine receptor (PBR, TSPO) without binding to other known neurotransmitter receptors. Also inhibits the human constitutive androstane receptor (hCAR).

Technical Data

M.Wt:
352.86
Formula:
C21H21ClN2O
Solubility:
Soluble to 50 mM in ethanol and to 50 mM in DMSO
Purity:
>98 %
Storage:
Store at RT
CAS No:
85532-75-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Li et al (2008) The peripheral benzodiazepine receptor ligand 1-(2-chlorophenyl-methylpropyl)-3-isoquinoline-carboxamide is a novel antagonist of human androstane receptor. Mol.Pharmacol. 74 443. PMID: 18492798.

Conway et al (1998) Temporal changes in glial fibrillary acidic protein messenger RNA and [3H]PK11195 binding in relation to imidazoline-I2-receptor and α2-adrenoceptor binding in the hippocampus following transient global forebrain ischaemia in the rat. Neuroscience 82 805. PMID: 9483537.

Le Fur et al (1983) Differentiation between two ligands for peripheral benzodiazpine binding sites [3H]-Ro 5-4864 and [3H]-PK11195, by thermodynamic studies. Life Sci. 33 449. PMID: 6308375.

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View Related Products by Product Action

Keywords: PK 11195, supplier, antagonists, peripheral, benzodiazepine, receptors, GABAA, Receptors, PK11195, PBR, TSPO, Tocris Bioscience, Translocator Protein Ligand products

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