PD 123319 ditrifluoroacetate

Cat. No. 1361

PD 123319 ditrifluoroacetate C31H32N4O3.2CF3CO2H [130663-39-7]

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Chemical Name: 1-[[4-(Dimethylamino)-3-methylphenyl]methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid ditrifluoroacetate

Biological Activity

Potent, selective, non-peptide angiotensin AT2 receptor antagonist. IC50 values are 34 and 210 nM in rat adrenal tissue and brain respectively.

Technical Data

M.Wt:
736.67
Formula:
C31H32N4O3.2CF3CO2H
Solubility:
Soluble to 100 mM in water
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
130663-39-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Tamura et al (2000) Induction of angiotensin II subtype 2 receptor-mediated blood pressure regulation in synthetic diet-fed rats. J.Hypertens. 18 1239. PMID: 10994755.

Boulay et al (1992) Modulation of angiotensin II binding affinity by allosteric interaction of polyvinyl sulfate with an intracellular domain of the DuP-753-sensitive angiotensin II receptor of bovine adrenal glomerulosa. Mol.Pharmacol. 41 809. PMID: 1569928.

Blankley et al (1991) Synthesis and structure-activity relationships of a novel series of non-peptide angiotensin II receptor binding inhibitors specific for the AT2 subtype. J.Med.Chem. 34 3248. PMID: 1956044.

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Citations are publications that use Tocris products. Selected citations for PD 123319 ditrifluoroacetate include:

Gu et al (2016) Angiotensin-converting enzyme 2 inhibits lung injury induced by respiratory syncytial virus. J Immunol 6 19840. PMID: 26813885.

Chang et al (2015) Vasculopathy-associated hyperangiotensinemia mobilizes haematopoietic stem cells/progenitors through endothelial AT2R and cytoskeletal dysregulation. Sci Rep 6 5914. PMID: 25574809.

Fan et al (2015) Local renin-angiotensin system regulates hypoxia-induced vascular endothelial growth factor synthesis in mesenchymal stem cells. Nat Commun 8 2505. PMID: 26045756.

Porter et al (2015) The angiotensin converting enzyme inhibitor, captopril, prevents the hyperactivity and impulsivity of neurokinin-1 receptor gene 'knockout' mice: sex differences and implications for the treatment of attention deficit hyperactivity disorder. Eur Neuropsychopharmacol 25 512. PMID: 25703442.

Skorska et al (2015) The CD4(+) AT2R(+) T cell subpopulation improves post-infarction remodelling and restores cardiac function. J Cell Mol Med 19 1975. PMID: 25991381.

Santiago et al (2014) High molecular weight fibroblast growth factor-2 in the human heart is a potential target for prevention of cardiac remodeling. PLoS One 9 e97281. PMID: 24827991.

Santollo et al (2014) Properly timed exposure to central ANG II prevents behavioral sensitization and changes in angiotensin receptor expression. Am J Physiol Regul Integr Comp Physiol 307 R1396. PMID: 25354729.

Speth et al (2014) Acute repeated intracerebroventricular injections of angiotensin II reduce agonist and antagonist radioligand binding in the paraventricular nucleus of the hypothalamus and median preoptic nucleus in the rat brain. Brain Res 1583 132. PMID: 25108041.

Speth et al (2014) Distribution of non-AT1, non-AT2 binding of 125I-sarcosine1, isoleucine8 angiotensin II in neurolysin knockout mouse brains. PLoS One 9 e105762. PMID: 25147932.

Chakrabarty et al (2013) Angiotensin II receptor type 2 activation is required for cutaneous sensory hyperinnervation and hypersensitivity in a rat hind paw model of inflammatory pain. J Pain 14 1053. PMID: 23726047.

Cruz et al (2013) High content screening of a kinase-focused library reveals compounds broadly-active against dengue viruses. PLoS Negl Trop Dis 7 e2073. PMID: 23437413.

Hong and Garvin (2012) Angiotensin II type 2 receptor-mediated inhibition of NaCl absorption is blunted in thick ascending limbs from Dahl salt-sensitive rats. Diabetes 60 765. PMID: 22777935.

Tsai et al (2012) Brain-derived neurotrophic factor ameliorates brain stem cardiovascular dysregulation during experimental temporal lobe status epilepticus. Am J Physiol Heart Circ Physiol 7 e33527. PMID: 22442695.

Hasin et al (2011) Angiotensin II signaling up-regulates the immediate early transcription factor ATF3 in the left but not the right atrium. Basic Res Cardiol 106 175. PMID: 21191795.

Santiago et al (2011) Preferential accumulation and export of high molecular weight FGF-2 by rat cardiac non-myocytes. Cardiovasc Res 89 139. PMID: 20696821.

Bourassa et al (2010) AT1 angiotensin II receptor and novel non-AT1, non-AT2 angiotensin II/III binding site in brainstem cardiovascular regulatory centers of the spontaneously hypertensive rat. Brain Res 1359 98. PMID: 20807518.

Curato et al (2010) Identification of noncytotoxic and IL-10-producing CD8+AT2R+ T cell population in response to ischemic heart injury. PLoS One 185 6286. PMID: 20935205.

Benkirane et al (2006) PPAR- γ inhibits ANG II-induced cell growth via SHIP2 and 4E-BP1. Hypertension 290 H390. PMID: 16155101.

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Keywords: PD 123319 ditrifluoroacetate, supplier, Potent, selective, non-peptide, AT2, antagonists, Receptors, Angiotensin, PD123319, ditrifluoroacetate, Tocris Bioscience, Angiotensin AT2 Receptor Antagonist products

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