Cat. No. 1375
Chemical Name: N-[3-Fluoro-5-(3-pyrindyl)phenyl]-2
Biological Activity5-HT2C/2B receptor antagonist (pKi values are 7.0, 8.1 and 9.1 at 5-HT2A, 2B and 2C receptors respectively). Displays inverse agonism in a 5-HT-stimulated PI hydrolysis model of 5-HT2C receptor function. Orally active in vivo.
Licensing InformationSold under license
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Bromidge et al (2000) Biarylcarbamoylindolines are novel and selective 5-HT2C receptor inverse agonists: identification of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]-5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a potential antidepressant/anxiolytic agent. J.Med.Chem. 43 1123. PMID: 10737744.
Reavill et al (1999) Attenuation of haloperidol-induced catalepsy by a 5-HT2C receptor antagonist. Br.J.Pharmacol. 126 572. PMID: 10188965.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses SB 228357 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: SB 228357, supplier, 5-HT2C, 5-HT2B, antagonists, inverse, agonists, Serotonin, Receptors, SB228357, Tocris Bioscience, 5-HT2C Receptor Antagonist products