SB 228357

Cat. No. 1375

SB 228357 C22H17F4N3O2	 [181629-93-6]

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Chemical Name: N-[3-Fluoro-5-(3-pyrindyl)phenyl]-2,3-dihydro-5-methoxy-6-(trifluoromethyl)-1H-indole-1-carboxamide

Biological Activity

5-HT2C/2B receptor antagonist (pKi values are 7.0, 8.1 and 9.1 at 5-HT2A, 2B and 2C receptors respectively). Displays inverse agonism in a 5-HT-stimulated PI hydrolysis model of 5-HT2C receptor function. Orally active in vivo.

Licensing Information

Sold under license

Technical Data

M.Wt:
431.39
Formula:
C22H17F4N3O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
181629-93-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Bromidge et al (2000) Biarylcarbamoylindolines are novel and selective 5-HT2C receptor inverse agonists: identification of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]-5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a potential antidepressant/anxiolytic agent. J.Med.Chem. 43 1123. PMID: 10737744.

Reavill et al (1999) Attenuation of haloperidol-induced catalepsy by a 5-HT2C receptor antagonist. Br.J.Pharmacol. 126 572. PMID: 10188965.

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Keywords: SB 228357, supplier, 5-HT2C, 5-HT2B, antagonists, inverse, agonists, Serotonin, Receptors, SB228357, Tocris Bioscience, 5-HT2C Receptor Antagonist products

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