PD 168077 maleate
Cat. No. 1065
Chemical Name: N-(Methyl-4-(2-cyanophenyl)piperazi
Biological ActivityA potent D4 dopamine receptor agonist (Ki = 8.7 nM) with > 400-fold selectivity over D2 and > 300-fold selectivity versus D3 subtypes respectively. Induces synaptic translocation of CaMK II to postsynaptic sites in cultured prefrontal cortical neurons. Centrally active in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Gu et al (2006) Activation of dopamine D4 receptors induces synaptic translocation of Ca2+/calmodulin-dependent protein kinase II in cultured prefrontal cortical neurons. Mol.Pharmacol. 69 813. PMID: 16365279.
Clifford and Waddington (2000) Topographically based search for an "Ethogram" among a series of novel D4 dopamine receptor agonists and antagonists. Neuropsychopharmacology 22 538. PMID: 10731629.
Glase et al (1997) Substituted [(4-phenylpiperazinyl)methyl]benzamides: selective dopamine D4 agonists. J.Med.Chem. 40 1771. PMID: 9191952.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses PD 168077 maleate from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: PD 168077 maleate, supplier, High, affinity, selective, D4, agonists, Dopamine, Receptors, dopaminergic, PD168077, maleate, Tocris Bioscience, D4 Receptor Agonist products
Find multiple products by catalog number
New Products in this Area
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.