Tetrodotoxin citrate

Cat. No. 1069

Tetrodotoxin citrate C11H17N3O8 [18660-81-6]

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Alternative Name: TTx citrate

Chemical Name: Octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethano-10aH-[1,3]dioxocino[6,5-d]pyrimidine-4,7,10,11,12-pentol citrate

Biological Activity

Highly selective, reversible sodium channel blocker; citrate salt of tetrodotoxin.

Technical Data

M.Wt:
319.27
Formula:
C11H17N3O8
Solubility:
Soluble to 100 mM in water
Storage:
Desiccate at -20°C
CAS No:
18660-81-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

Gleitz et al (1996) The protective action of tetrodotoxin and (±)-kavain on anaerobic glycolysis, ATP content and intracellular Na+ and Ca2+ of anoxic brain vesicles. Neuropharmacology 35 1743. PMID: 9076753.

Kao (1986) Structure-activity relations of tetrodotoxin, saxitoxin, and analogues. Ann.N.Y.Acad.Sci. 479 52. PMID: 2434008.

Kao (1972) Pharmacology of tetrodotoxin and saxitoxin. Fed.Proc. 31 1117. PMID: 5032475.

Merck Index 12 9382.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Tetrodotoxin citrate include:

Cichon and Gan (2015) Branch-specific dendritic Ca(2+) spikes cause persistent synaptic plasticity. Nature 520 180. PMID: 25822789.

Dieck et al (2015) Direct visualization of newly synthesized target proteins in situ. Nat Methods 12 411. PMID: 25775042.

Ouwenga and Dougherty (2015) Fmrp targets or not: long, highly brain-expressed genes tend to be implicated in autism and brain disorders. Mol Autism 6 16. PMID: 25789151.

Halff et al (2014) A novel mechanism for nicotinic potentiation of glutamatergic synapses. J Neurosci 34 2051. PMID: 24501347.

Bloodgood et al (2013) The activity-dependent transcription factor NPAS4 regulates domain-specific inhibition. Nature 503 121. PMID: 24201284.

Evans et al (2013) Dynamic interactions mediated by nonredundant signaling mechanisms couple circadian clock neurons. Neuron 80 973. PMID: 24267653.

Montgomery et al (2013) Mis-expression of the BK K(+) channel disrupts suprachiasmatic nucleus circuit rhythmicity and alters clock-controlled behavior. Am J Physiol Cell Physiol 304 C299. PMID: 23174562.

Ren et al (2013) Direct retino-raphe projection alters serotonergic tone and affective behavior. Neuropsychopharmacology 38 1163. PMID: 23370156.

Janssen et al (2012) Neuregulin directly decreases voltage-gated sodium current in hippocampal ErbB4-expressing interneurons. J Neurosci 32 13889. PMID: 23035098.

Jurgens et al (2012) Optogenetic stimulation of the corticothalamic pathway affects relay cells and GABAergic neurons differently in the mouse visual thalamus. PLoS One 7 e45717. PMID: 23029198.

Tozzi et al (2012) A2A adenosine receptor antagonism enhances synaptic and motor effects of cocaine via CB1 cannabinoid receptor activation. PLoS One 7 e38312. PMID: 22715379.

Calloe et al (2011) Multiple arrhythmic syndromes in a newborn, owing to a novel mutation in SCN5A. Can J Physiol Pharmacol 89 723. PMID: 21895525.

Specht et al (2011) Regulation of glycine receptor diffusion properties and gephyrin interactions by protein kinase C. EMBO J 30 3842. PMID: 21829170.

Stacpoole et al (2011) Efficient derivation of NPCs, spinal motor neurons and midbrain dopaminergic neurons from hESCs at 3% oxygen. Nat Protoc 6 1229. PMID: 21799491.

Vornanen et al (2011) Tetrodotoxin sensitivity of the vertebrate cardiac Na+ current. Mar Drugs 9 2409. PMID: 22163193.

Zemkova et al (2011) Norepinephrine causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+. Endocrinology 152 3842. PMID: 21828176.

Lee and Tepper (2007) A calcium-activated nonselective cation conductance underlies the plateau potential in rat substantia nigra GABAergic neurons. J Neurosci 27 6531. PMID: 17567814.

Khan et al (2006) Pharmacological characterization of endothelin receptors-mediated contraction in the mouse isolated proximal and distal colon. Br J Pharmacol 147 607. PMID: 16432510.

Do you know of a great paper that uses Tetrodotoxin citrate from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: Tetrodotoxin citrate, supplier, Citrate, salt, Sodium, NaV, Channels, voltage-gated, voltage-dependent, Na+, Tocris Bioscience, Voltage-gated Sodium (NaV) Channel Blocker products

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