Oxotremorine M

Cat. No. 1067

Oxotremorine M C11H19IN2O [3854-04-4]

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Chemical Name: N,N,N-Trimethyl-4-(2-oxo-1-pyrolidinyl)-2-butyn-1-ammonium iodide

Biological Activity

Muscarinic receptor agonist.

Technical Data

M.Wt:
322.19
Formula:
C11H19IN2O
Solubility:
Soluble to 100 mM in water
Purity:
>98 %
Storage:
Desiccate at -20°C
CAS No:
3854-04-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Kukkonen et al (1996) Functional properties of muscarinic receptor subtypes Hm1, Hm3 and Hm5 expressed in Sf9 cells using the baculovirus expression system. J.Pharmacol.Exp.Ther. 279 593. PMID: 8930161.

Birdsall et al (1978) The binding of agonists to brain muscarinic receptors. Mol.Pharmacol. 14 723. PMID: 714021.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Oxotremorine M include:

Abiraman et al (2015) Anti-muscarinic adjunct therapy accelerates functional human oligodendrocyte repair. PLoS One 35 3676. PMID: 25716865.

Parent et al (2015) Cholinergic and ghrelinergic receptors and KCNQ channels in the medial PFC regulate the expression of palatability. Proc Natl Acad Sci U S A 9 284. PMID: 26578914.

Roberts-Crowley and Rittenhouse (2015) Characterization of ST14A Cells for Studying Modulation of Voltage-Gated Calcium Channels. Front Behav Neurosci 10 e0132469. PMID: 26147123.

Shin et al (2015) Muscarinic regulation of dopamine and glutamate transmission in the nucleus accumbens. J Neurosci 112 8124. PMID: 26080439.

Daigle and Caron (2012) Elimination of GRK2 from cholinergic neurons reduces behavioral sensitivity to muscarinic receptor activation. J Neurosci 32 11461. PMID: 22895728.

Buchanan et al (2010) Facilitation of long-term potentiation by muscarinic M(1) receptors is mediated by inhibition of SK channels. Neuron 68 948. PMID: 21145007.

Filippov et al (2010) The scaffold protein NHERF2 determines the coupling of P2Y1 nucleotide and mGluR5 glutamate receptor to different ion channels in neurons. PLoS One 30 11068. PMID: 20720114.

Narushima et al (2007) Tonic enhancement of endocannabinoid-mediated retrograde suppression of inhibition by cholinergic interneuron activity in the striatum. J Neurosci 27 496. PMID: 17234582.

Do you know of a great paper that uses Oxotremorine M from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: Oxotremorine M, supplier, Muscarinic, agonists, Receptors, Acetylcholine, ACh, OxotremorineM, Tocris Bioscience, Non-selective Muscarinic Agonist products

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