Cat. No. 0238
Alternative Name: L-SOP
Chemical Name: L-Serine-O-phosphate
Biological ActivityGroup III metabotropic glutamate receptor agonist; analog of L-AP4 (Cat. No. 0103). Neuroprotective against excitotoxicity in cortical cell cultures. Inhibits proliferation and enhances neuronal differentiation in progenitor cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Yang et al (2016) A chemical biology route to site-specific authentic protein modifications. Science 354 623. PMID: 27708052.
Park et al (2011) Expanding the genetic code of Escherichia coli with phosphoserine. Science 333 1151. PMID: 21868676.
Saxe et al (2007) A phenotypic small-molecule screen identifies an orphan ligand-receptor pair that regulates neural stem cell differentiation. Chem.Biol. 14 1019. PMID: 17884634.
Bruno et al (1996) Activation of group III metabotropic glutamate receptors is neuroprotective in cortical cultures. Eur.J.Pharmacol. 310 61. PMID: 8880068.
Eriksen and Thomsen (1995) [3H]-L-2-amino-4-phosphonobutyrate labels a metabotropic glutamate receptor, mGluR4a. Br.J.Pharmacol. 116 3279. PMID: 8719808.
Thoreson and Ulphani (1995) Pharmacology of selective and non-selective metabotropic glutamate receptor agonists at L-AP4 receptors in ON bipolar cells. Brain Res. 676 93. PMID: 7796182.
If you know of a relevant reference for O-Phospho-L-serine please let us know.
Citations are publications that use Tocris products. Selected citations for O-Phospho-L-serine include:
Mathiesen et al (2003) Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP. Br J Pharmacol 138 1026. PMID: 12684257.
Do you know of a great paper that uses O-Phospho-L-serine from Tocris? If so please let us know.
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Keywords: O-Phospho-L-serine, supplier, Group, III, mGlur, agonists, Receptors, mGlu4, mGlu6, mGlu7, mGlu8, mGluR4, mGluR6, mGluR7, mGluR8, Glutamate, Metabotropic, stem, cells, o-phosphoserine, sep, Tocris Bioscience, Glutamate (Metabotropic) Group III Receptor Agonist products