SC 19220

Cat. No. 1206

SC 19220 C16H14ClN3O3 [19395-87-0]

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Chemical Name: 8-Chloro-dibenzo(Z)[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-acetylhydrazide

Biological Activity

Selective EP1 receptor antagonist (IC50 = 6.7 μM for inhibition of [3H]-PGE2 binding to EP1 transfected COS cells).

Technical Data

M.Wt:
331.76
Formula:
C16H14ClN3O3
Solubility:
Soluble to 25 mM in ethanol with gentle warming and to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
19395-87-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Botella et al (1995) Receptor subtypes involved in dual effects induced by prostaglandin E2 in circular smooth muscle from dog colon. J.Pharmacol.Exp.Ther. 273 1008. PMID: 7791070.

Funk et al (1993) Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype. J.Biol.Chem. 268 26767. PMID: 8253813.

Sanner (1972) Dibenzoxazepine hydrazides as prostaglandin antagonists. Intra-Science Chem.Rept. 6 1.

If you know of a relevant reference for SC 19220 please let us know.

Citations are publications that use Tocris products. Selected citations for SC 19220 include:

Passafaro et al (2011) Cholinergic Autoantibodies from Primary Sjögren's Syndrome Inhibit Mucin Production via Phospholipase C and Cyclooxygenase-2 In the Rat Submandibular Gland. Neuropharmacology 8 138. PMID: 22013477.

Do you know of a great paper that uses SC 19220 from Tocris? If so please let us know.

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Keywords: SC 19220, supplier, Selective, EP1, receptor, antagonist, Receptors, Prostanoids, prostaglandins, prostacyclins, eicosanoids, SC19220, Tocris Bioscience, Prostanoid Receptor Antagonist products

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