Cat. No. 1206
Chemical Name: 8-Chloro-dibenzo(Z)[b,f][1,4]oxazep
Biological ActivitySelective EP1 receptor antagonist (IC50 = 6.7 μM for inhibition of [3H]-PGE2 binding to EP1 transfected COS cells).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Botella et al (1995) Receptor subtypes involved in dual effects induced by prostaglandin E2 in circular smooth muscle from dog colon. J.Pharmacol.Exp.Ther. 273 1008. PMID: 7791070.
Funk et al (1993) Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype. J.Biol.Chem. 268 26767. PMID: 8253813.
Sanner (1972) Dibenzoxazepine hydrazides as prostaglandin antagonists. Intra-Science Chem.Rept. 6 1.
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Citations are publications that use Tocris products. Selected citations for SC 19220 include:
Passafaro et al (2011) Cholinergic Autoantibodies from Primary Sjögren's Syndrome Inhibit Mucin Production via Phospholipase C and Cyclooxygenase-2 In the Rat Submandibular Gland. Neuropharmacology 8 138. PMID: 22013477.
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Keywords: SC 19220, supplier, Selective, EP1, receptor, antagonist, Receptors, Prostanoids, prostaglandins, prostacyclins, eicosanoids, SC19220, Tocris Bioscience, Prostanoid Receptor Antagonist products
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