Phorbol 12-myristate 13-acetate

Cat. No. 1201

Phorbol 12-myristate 13-acetate C36H56O8 [16561-29-8]

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Alternative Name: PMA

Chemical Name: (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a- (Acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-yl tetradecanoate

Biological Activity

Extensively used phorbol ester activator of protein kinase C; tumor promoter. Binds to PKC with a Ki value of 2.6 nM as measured by displacement of [3H]phorbol 12,13-dibutyrate binding in rat cortex synaptosomal membranes.

Technical Data

M.Wt:
616.83
Formula:
C36H56O8
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at -20°C
CAS No:
16561-29-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Murphy et al (1999) Structural determinants of phorbol ester binding in synaptosomes: pharmacokinetics and pharmacodynamics. Eur.J.Pharmacol. 381 77. PMID: 10528137.

Hockberger et al (1989) A diacylglycerol analogue reduces neuronal calcium currents independently of protein kinase C activation. Nature 338 340. PMID: 2922062.

Castagna et al (1982) Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters. J.Biol.Chem. 257 7847. PMID: 7085651.

Merck Index 12 7487.

If you know of a relevant reference for Phorbol 12-myristate 13-acetate please let us know.

Citations are publications that use Tocris products. Selected citations for Phorbol 12-myristate 13-acetate include:

Quizon (2016) Molecular mechanism: the human dopamine transporter histidine 547 regulates basal and HIV-1 Tatprotein-inhibited dopamine transport. Scientific Reports 6 39048. PMID: 27966610.

Bemben et al (2015) Autism-associated mutation inhibits protein kinase C-mediated neuroligin-4X enhancement of excitatory synapses. Proc Natl Acad Sci U S A 112 2551. PMID: 25675530.

Brust et al (2015) New functional activity of aripiprazole revealed: Robust antagonism of D2 dopamine receptor-stimulated Gβγ signaling. J Vis Exp 93 85. PMID: 25449598.

Davis (2015) The ATP-Binding Cassette Transporter-2 (ABCA2) Overexpression Modulates Sphingosine Levels and Transcription of the Amyloid Precursor Protein (APP) Gene. Biochem Pharmacol 12 847. PMID: 26510981.

Hagen et al (2015) Comparative Multi-Donor Study of IFNγ Secretion and Expression by Human PBMCs Using ELISPOT Side-by-Side with ELISA and Flow Cytometry Assays. Cells 4 84. PMID: 25679284.

Brown et al (2014) Mitogen-activated protein kinase-interacting kinase regulates mTOR/AKT signaling and controls the serine/arginine-rich protein kinase-responsive type 1 internal ribosome entry site-mediated translation and viral oncolysis. J Pharmacol Exp Ther 88 13149. PMID: 25187540.

Walsh et al (2014) The role of Nox1 and Nox2 in GPVI-dependent platelet activation and thrombus formation. Redox Biol 2 178. PMID: 24494191.

Yu et al (2014) Transactivation of epidermal growth factor receptor through platelet-activating factor/receptor in ovarian cancer cells. J Exp Clin Cancer Res 33 85. PMID: 25261977.

Gabriel et al (2012) The acid-sensitive, anesthetic-activated potassium leak channel, KCNK3, is regulated by 14-3-3β-dependent, protein kinase C (PKC)-mediated endocytic trafficking. J Biol Chem 287 32354. PMID: 22846993.

Gao et al (2012) Transient receptor potential vanilloid type 1-dependent regulation of liver-related neurons in the paraventricular nucleus of the hypothalamus diminished in the type 1 diabetic mouse. J Virol 61 1381. PMID: 22492526.

Kapfhammer and Gugger (2012) The analysis of purkinje cell dendritic morphology in organotypic slice cultures. J Biol Chem NULL. PMID: 22473312.

Kaszás et al (2012) Small molecule positive allosteric modulation of TRPV1 activation by vanilloids and acidic pH. J Neurosci 340 152. PMID: 22005042.

Navaroli et al (2011) The plasma membrane-associated GTPase Rin interacts with the dopamine transporter and is required for protein kinase C-regulated dopamine transporter trafficking. J Neurosci 31 13758. PMID: 21957239.

Specht et al (2011) Regulation of glycine receptor diffusion properties and gephyrin interactions by protein kinase C. EMBO J 30 3842. PMID: 21829170.

Zsombok et al (2011) Functional plasticity of central TRPV1 receptors in brainstem dorsal vagal complex circuits of streptozotocin-treated hyperglycemic mice. Curr Alzheimer Res 31 14024. PMID: 21957263.

Bohnekamp et al (2010) Involvement of the chemokine-like receptor GPR33 in innate immunity. Br J Pharmacol 396 272. PMID: 20399748.

Nishida et al (2009) Inhibition of ATR protein kinase activity by schisandrin B in DNA damage response. Nucleic Acids Res 37 5678. PMID: 19625493.

Jones et al (2004) Regulation of SHP-1 tyrosine phosphatase in human platelets by serine phosphorylation at its C terminus. Biochem Biophys Res Commun 279 40475. PMID: 15269224.

Do you know of a great paper that uses Phorbol 12-myristate 13-acetate from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: Phorbol 12-myristate 13-acetate, supplier, Protein, kinases, C, activators, PKC, Phorbol12-myristate13-acetate, Tocris Bioscience, Protein Kinase C Activator products

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