Phorbol 12-myristate 13-acetate

Cat. No. 1201

Phorbol 12-myristate 13-acetate C36H56O8 [16561-29-8]

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Alternative Name: PMA

Chemical Name: (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a- (Acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-yl tetradecanoate

Biological Activity

Extensively used phorbol ester activator of protein kinase C; tumor promoter. Binds to PKC with a Ki value of 2.6 nM as measured by displacement of [3H]phorbol 12,13-dibutyrate binding in rat cortex synaptosomal membranes.

Technical Data

M.Wt:
616.83
Formula:
C36H56O8
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at -20°C
CAS No:
16561-29-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

Murphy et al (1999) Structural determinants of phorbol ester binding in synaptosomes: pharmacokinetics and pharmacodynamics. Eur.J.Pharmacol. 381 77. PMID: 10528137.

Hockberger et al (1989) A diacylglycerol analogue reduces neuronal calcium currents independently of protein kinase C activation. Nature 338 340. PMID: 2922062.

Castagna et al (1982) Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters. J.Biol.Chem. 257 7847. PMID: 7085651.

Merck Index 12 7487.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Phorbol 12-myristate 13-acetate include:

Bemben et al (2015) Autism-associated mutation inhibits protein kinase C-mediated neuroligin-4X enhancement of excitatory synapses. Proc Natl Acad Sci U S A 112 2551. PMID: 25675530.

Hagen et al (2015) Comparative Multi-Donor Study of IFNγ Secretion and Expression by Human PBMCs Using ELISPOT Side-by-Side with ELISA and Flow Cytometry Assays. Cells 4 84. PMID: 25679284.

Walsh et al (2014) The role of Nox1 and Nox2 in GPVI-dependent platelet activation and thrombus formation. Redox Biol 2 178. PMID: 24494191.

Yu et al (2014) Transactivation of epidermal growth factor receptor through platelet-activating factor/receptor in ovarian cancer cells. J Exp Clin Cancer Res 33 85. PMID: 25261977.

Gabriel et al (2012) The acid-sensitive, anesthetic-activated potassium leak channel, KCNK3, is regulated by 14-3-3β-dependent, protein kinase C (PKC)-mediated endocytic trafficking. J Biol Chem 287 32354. PMID: 22846993.

Navaroli et al (2011) The plasma membrane-associated GTPase Rin interacts with the dopamine transporter and is required for protein kinase C-regulated dopamine transporter trafficking. J Neurosci 31 13758. PMID: 21957239.

Specht et al (2011) Regulation of glycine receptor diffusion properties and gephyrin interactions by protein kinase C. EMBO J 30 3842. PMID: 21829170.

Nishida et al (2009) Inhibition of ATR protein kinase activity by schisandrin B in DNA damage response. Nucleic Acids Res 37 5678. PMID: 19625493.

Do you know of a great paper that uses Phorbol 12-myristate 13-acetate from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: Phorbol 12-myristate 13-acetate, supplier, Protein, kinases, C, activators, PKC, Phorbol12-myristate13-acetate, Tocris Bioscience, Protein Kinase C Activator products

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