Nω-Propyl-L-arginine hydrochloride

Cat. No. 1200

Nw-Propyl-L-arginine hydrochloride C9H20N4O2.HCl [137361-05-8]

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Chemical Name: N5-[Imino(propylamino)methyl]-L-ornithine hydrochloride

Biological Activity

Highly selective and potent inhibitor of nNOS (Ki = 57 nM). Displays 3158-fold and 149-fold selectivity over iNOS and eNOS respectively. Hypotensive in vivo.

Licensing Information

Sold under license.

Technical Data

M.Wt:
252.74
Formula:
C9H20N4O2.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
137361-05-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

Kakoki et al (2001) The influence of nitric oxide synthase 1 on blood flow and interstitial nitric oxide in the kidney. Am.J.Physiol.Regul.Integr.Comp.Physiol. 281 R91. PMID: 11404282.

Zhang et al (1997) Potent and selective inhibition of neuronal nitric oxide synthase by Nω-propyl-L-arginine. J.Med.Chem. 40 3869. PMID: 9397167.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Nω-Propyl-L-arginine hydrochloride include:

Mathison et al (2004) Effects of cannabinoid receptor-2 activation on accelerated gastrointestinal transit in lipopolysaccharide-treated rats. Br J Pharmacol 142 1247. PMID: 15249429.

Slesinger (2001) Ion selectivity filter regulates local anesthetic inhibition of G-protein-gated inwardly rectifying K+ channels. Biophys J 80 707. PMID: 11159438.

Do you know of a great paper that uses Nω-Propyl-L-arginine hydrochloride from Tocris? If so please let us know.

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