SB 200646 hydrochloride

Cat. No. 1371

SB 200646 hydrochloride C15H14N4O.HCl [143797-62-0]

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Chemical Name: N-(1-Methyl-1H-indol-5-yl)-N'-3-pyridinylurea

Biological Activity

5-HT2C/2B receptor antagonist, selective over 5-HT1A. Affinities are 7.4 (pA2), 6.9 (pKi) and 5.2 (pKi) for 5-HT2B, 2C and 2A respectively. Orally active in vivo.

Licensing Information

Sold under license

Technical Data

M.Wt:
302.76
Formula:
C15H14N4O.HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at RT
CAS No:
143797-62-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Kennett et al (1995) Effect of SB 200646A, a 5-HT2C/5-HT2B receptor antagonist, in two conflict models of anxiety. Psychopharmacology (Berl.) 118 178. PMID: 7617805.

Kennett et al (1994) In vivo properties of SB 200646A, a 5-HT2C/2B recepor antagonist. Br.J.Pharmacol. 111 797. PMID: 7912626.

Forbes et al (1993) N-(1-Methyl-5-indolyl)-N'-(3-pyridyl)urea hydrochloride: the first selective 5-HT1C receptor antagonist. J.Med.Chem. 36 1104. PMID: 8478907.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for SB 200646 hydrochloride include:

Xiao et al (2008) Release of glutamate and CGRP from trigeminal ganglion neurons: Role of calcium channels and 5-HT1 receptor signaling. Am J Physiol Endocrinol Metab 4 12. PMID: 18416824.

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