SB 204070

Cat. No. 1373

SB 204070 C19H27ClN2O4.HCl [148688-01-1]

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Chemical Name: 8-Amino-7-chloro-2,3-dihydro-1,4-benzodioxan-5-carboxylic acid, 1'-butyl-4'-piperidinylmethyl ester

Biological Activity

Potent and selective 5-HT4 receptor antagonist (pIC50 = 10.1). Displays >5000-fold selectivity for 5-HT4 over 5-HT1A, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2C, and 5-HT3 receptors. Exhibits anxiolytic activity upon systemic administration in vivo.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline.

Technical Data

M.Wt:
419.34
Formula:
C19H27ClN2O4.HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
148688-01-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Prins et al (2000) An improved in vitro bioassay for the study of 5-HT4 receptors in the human isolated large intestine circular muscle. Br.J.Pharmacol. 129 1601. PMID: 10780964.

Bingham et al (1995) Antagonism by SB 204070 of 5-HT-evoked contractions in the dog stomach: an in-vivo model of 5-HT4 receptor function. J.Pharm.Pharmacol. 47 219. PMID: 7602484.

Gaster et al (1993) (1-Butyl-4-piperidinyl)methyl 8-amino-7-chloro-1,4-benzodioxane-5-carboxylate hydrochloride: a highly potent and selective 5-HT4 antagonist derived from metoclopramide. J.Med.Chem. 36 4121. PMID: 8258837.

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Keywords: SB 204070, supplier, Serotonin, serotonergics, selective, 5-HT4, receptors, antagonists, anxiolytics, SB204070, Tocris Bioscience, 5-HT4 Receptor Antagonist products

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