4-PPBP maleate

Cat. No. 0620

4-PPBP maleate C21H27N.C4H4O4 [201216-39-9]

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Chemical Name: 4-Phenyl-1-(4-phenylbutyl)piperidine maleate

Biological Activity

σ ligand and selective non-competitive antagonist at recombinant NR1a/2B NMDA receptors expressed in Xenopus oocytes.

Technical Data

Soluble to 25 mM in ethanol and to 25 mM in DMSO
>99 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Whittemore et al (1997) Antagonism of N-methyl-D-aspartate receptors by σ site ligands: potency, subtype-selectivity and mechanisms of inhibition. J.Pharmacol.Exp.Ther. 282 326. PMID: 9223571.

Glennon et al (1991) Novel 1-phenylpiperazine and 4-phenylpiperidine derivatives as high affinity σ ligands. J.Med.Chem. 34 3360. PMID: 1662725.

If you know of a relevant reference for 4-PPBP maleate please let us know.

Citations are publications that use Tocris products. Selected citations for 4-PPBP maleate include:

Yang et al (2007) σ receptor agonists provide neuroprotection in vitro by preserving bcl-2. Front Behav Neurosci 104 1179. PMID: 17456670.

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Keywords: 4-PPBP maleate, supplier, Specific, σ, sigma, ligand, NMDA, antagonists, Receptors, Tocris Bioscience, Sigma-Related Ligand products

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