Cat. No. 1060
Chemical Name: (S)-1-(1H-indol-4-yloxy)-3-[(1-meth
Biological Activity5-HT1A/1B receptor antagonist, with roughly equal affinity for each subtype. A partial agonist at mouse and human β3-adrenoceptors. More active enantiomer of pindolol (Cat. No. 0994).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Corradetti et al (1998) Antagonist properties of (-)-pindolol and WAY 100635 at somatodendritic and postsynaptic 5-HT1A receptors in the rat brain. Br.J.Pharmacol. 123 449. PMID: 9504386.
Kalkman (1989) β-Adrenoceptor blockade in rats enhances the ambulation induced by 5-HT1A receptor agonists. Eur.J.Pharmacol. 173 121. PMID: 2576226.
Walter et al (1984) Stimulant and blocking effects of optical isomers of pindolol on the sinoatrial node and trachea of guinea pig. Role of β-adrenoceptor subtypes in the dissociation between blockade and stimulation. Naunyn Schmiedebergs Arch.Pharmacol. 327 159. PMID: 6092972.
If you know of a relevant reference for (S)-(-)-Pindolol please let us know.
Citations are publications that use Tocris products. Selected citations for (S)-(-)-Pindolol include:
Kaya et al (2009) Coupling of β2-adrenoceptors to XLαs and Gαs: a new insight into ligand-induced G protein activation. Front Neurosci 329 350. PMID: 19144685.
Do you know of a great paper that uses (S)-(-)-Pindolol from Tocris? If so please let us know.
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Keywords: (S)-(-)-Pindolol, supplier, β3-adrenoceptor, b3-adrenoceptor, β3-adrenergic, b3-adrenergic, partial, agonists, Serotonin, 5-HT1A, Receptors, 5-HT1B, Tocris Bioscience, Adrenergic β3 Receptor Agonist products