(S)-(-)-Pindolol

Cat. No. 1060

(S)-(-)-Pindolol C14H20N2O2 [26328-11-0]

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Chemical Name: (S)-1-(1H-indol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol

Biological Activity

5-HT1A/1B receptor antagonist, with roughly equal affinity for each subtype. A partial agonist at mouse and human β3-adrenoceptors. More active enantiomer of pindolol (Cat. No. 0994).

Technical Data

M.Wt:
248.32
Formula:
C14H20N2O2
Solubility:
Soluble to 100 mM in 1eq. HCl
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
26328-11-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

Corradetti et al (1998) Antagonist properties of (-)-pindolol and WAY 100635 at somatodendritic and postsynaptic 5-HT1A receptors in the rat brain. Br.J.Pharmacol. 123 449. PMID: 9504386.

Kalkman (1989) β-Adrenoceptor blockade in rats enhances the ambulation induced by 5-HT1A receptor agonists. Eur.J.Pharmacol. 173 121. PMID: 2576226.

Walter et al (1984) Stimulant and blocking effects of optical isomers of pindolol on the sinoatrial node and trachea of guinea pig. Role of β-adrenoceptor subtypes in the dissociation between blockade and stimulation. Naunyn Schmiedebergs Arch.Pharmacol. 327 159. PMID: 6092972.

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Keywords: (S)-(-)-Pindolol, supplier, β3-adrenoceptor, b3-adrenoceptor, β3-adrenergic, b3-adrenergic, partial, agonists, Serotonin, 5-HT1A, Receptors, 5-HT1B, Tocris Bioscience, Adrenergic β3 Receptor Agonist products

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