BW 723C86 hydrochloride

Cat. No. 1059

BW 723C86 hydrochloride C16H18N2OS.HCl [160521-72-2]

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Chemical Name: α-methyl-5-(2-thienylmethoxy)-1H-indole-3-ethanamine hydrochloride

Biological Activity

Selective 5-HT2B receptor agonist.

Technical Data

M.Wt:
322.85
Formula:
C16H18N2OS.HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
160521-72-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Niebert et al (2011) Expression and function of serotonin 2A and 2B receptors in the mammalian respiratory network. PLoS One 6 e21395. PMID: 21789169.

Kennett et al (1998) Anxiolytic-like actions of BW 723C86 in the rat Vogel conflict test are 5-HT2B receptor mediated. Neuropharmacology 37 1603. PMID: 9886683.

Duxon et al (1997) Activation of 5-HT2B receptors in the medial amygdala causes anxiolysis in the social interaction test in the rat. Neuropharmacology 36 601. PMID: 9225285.

Kennett et al (1997) BW 723C86, a 5-HT2B receptor agonist, causes hyperphagia and reduced grooming in rats. Neuropharmacology 36 233. PMID: 9144661.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for BW 723C86 hydrochloride include:

Gerhold et al (2015) Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude. J Neurosci 35 9580. PMID: 26134641.

Watts et al (2015) 5-HT is a potent relaxant in rat superior mesenteric veins. PLoS One 3 e00103. PMID: 25692021.

Hernandez et al (2012) Mammary gland serotonin regulates parathyroid hormone-related protein and other bone-related signals. Pharmacol Res Perspect 302 E1009. PMID: 22318950.

Niebert et al (2011) Expression and function of serotonin 2A and 2B receptors in the mammalian respiratory network. J Pharmacol Exp Ther 6 e21395. PMID: 21789169.

Wouters et al (2009) Protein kinase C{gamma} mediates regulation of proliferation by the serotonin 5-hydroxytryptamine receptor 2B. J Biol Chem 284 21177. PMID: 19531484.

Do you know of a great paper that uses BW 723C86 hydrochloride from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: BW 723C86 hydrochloride, supplier, 5-HT2B, agonist, Serotonin, Receptors, BW723C86, hydrochloride, Tocris Bioscience, 5-HT2B Receptor Agonist products

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