WIN 64338 hydrochloride

Cat. No. 1057

WIN 64338 hydrochloride C45H68ClN4OP.HCl [163727-74-0]

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Chemical Name: (S)-4-[2-[Bis(cyclohexylamino)methyleneamino]-3-(2-naphthalenyl)-1-oxopropylamino]benzyl tributyl phosphonium chloride hydrochloride

Biological Activity

The first potent, non-peptide, competitive bradykinin B2 receptor antagonist. In organ bath studies, WIN 64338 inhibits [3H]-bradykinin binding on guinea pig trachea with nanomolar affinity but is not active in the rabbit aorta (the classical bradykinin B1 preparation).

Technical Data

M.Wt:
783.95
Formula:
C45H68ClN4OP.HCl
Solubility:
Soluble to 75 mM in DMSO
Storage:
Desiccate at +4°C
CAS No:
163727-74-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Hu et al (2004) Action of bradykinin in the submucosal plexus of guinea pig small intestine. J.Pharmacol.Exp.Ther. 309 320. PMID: 14718600.

Scherrer et al (1995) Effects of WIN 64338, a nonpeptide bradykinin B2 receptor antagonist, on guinea-pig trachea. Br.J.Pharmacol. 115 1127. PMID: 7582533.

Marceau et al (1994) Effects of peptide and nonpeptide antagonists of bradykinin B2 receptors on the venoconstrictor action of bradykinin. J.Pharmacol.Exp.Ther. 269 1136. PMID: 8014858.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for WIN 64338 hydrochloride include:

Gross et al (2013) Factors mediating remote preconditioning of trauma in the rat heart: central role of the cytochrome p450 epoxygenase pathway in mediating infarct size reduction. J Cardiovasc Pharmacol Ther 18 38. PMID: 22407888.

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Keywords: WIN 64338 hydrochloride, supplier, Bradykinin, B2, antagonists, Receptors, WIN64338, hydrochloride, Tocris Bioscience, Bradykinin Receptor Antagonist products

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