GR 55562 dihydrochloride

Cat. No. 1054

GR 55562 dihydrochloride C23H25N3O2.2HCl [159533-25-2]

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Chemical Name: 3-[3-(Dimethylamino)propyl]-4-hydroxy-N-[4-(4-pyridinyl)phenyl]benzamide dihydrochloride

Biological Activity

A selective competitive 5-HT1B (5-HT1Dβ) silent antagonist with pKB values of 7.3 and 6.3 for human cloned 5-HT1B and 5-HT1D receptors respectively and only weak binding at a number of other 5-HT subtypes.

Licensing Information

Sold with the permission of GlaxoSmithKline

Technical Data

M.Wt:
448.39
Formula:
C23H25N3O2.2HCl
Solubility:
Soluble to 100 mM in water
Purity:
>98 %
Storage:
Desiccate at +4°C
CAS No:
159533-25-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
Select another batch:

MacLean et al (1996) Evidence for 5-HT1-like receptor-mediated vasoconstriction in human pulmonary artery. Br.J.Pharmacol. 119 277. PMID: 8886409.

Connor et al (1995) Use of GR55562, a selective 5-HT1D antagonist, to investigate 5-HT1D receptor subtypes mediating cerebral vasoconstriction. Cephalalgia 15 (suppl. 14) 99.

Walsh et al (1995) The activity of 5-HT1D receptor ligands at cloned human 5-HT1Dα and 5-HT1Dβ receptors. Eur.J.Pharmacol. 287 79. PMID: 8666030.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for GR 55562 dihydrochloride include:

Johansson et al (2012) Expressional changes in cerebrovascular receptors after experimental transient forebrain ischemia. PLoS One 7 e41852. PMID: 22848635.

Morecroft et al (2010) In vivo effects of a combined 5-HT1B receptor/SERT antagonist in experimental pulmonary hypertension. Exp Eye Res 85 593. PMID: 19736308.

Wei et al (2010) JNK regulates serotonin-mediated proliferation and migration of pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 298 L863. PMID: 20228179.

Müller et al (2009) 5-hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo. PLoS One 4 e6453. PMID: 19649285.

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Keywords: GR 55562 dihydrochloride, supplier, 5-HT1B, antagonists, Serotonin, Receptors, GR55562, dihydrochloride, GlaxoSmithKline, GSK, Tocris Bioscience, 5-HT1B Receptor Antagonist products

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