Cat. No. 1377

Cromakalim C16H18N2O3 [94470-67-4]

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Alternative Name: BRL 34915

Chemical Name: trans-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile

Biological Activity

Prototypical Kir6 (KATP) channel opener. Relaxes rabbit isolated portal vein with an IC50 value of 21 nM . Potent, orally active and hypotensive in vivo.

Licensing Information

Sold under license

Technical Data

Soluble to 20 mM in DMSO
>99 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Escande et al (1988) The potassium channel opener cromakalim (BRL 34915) activates ATP-dependent K+ channels in isolated cardiac myocytes. Biochem.Biophys.Res.Commun. 154 620. PMID: 2456760.

Longman et al (1988) Cromakalim, a potassium channel activator: a comparison of its cardiovascular haemodynamic profile and tissue specificity with those of pinacidil and nicorandil. J.Cardiovasc.Pharmacol. 12 535. PMID: 2468052.

Wilson et al (1988) Comparative effects of K+ channel blockade on the vasorelaxant activity of cromakalim, pinacidil and nicorandil. Eur.J.Pharmacol. 152 331. PMID: 2851450.

If you know of a relevant reference for Cromakalim please let us know.

Citations are publications that use Tocris products. Selected citations for Cromakalim include:

Mehmood et al (2015) Antidiarrhoeal, antisecretory and antispasmodic activities of Matricaria chamomilla are mediated predominantly through K(+)-channels activation. PLoS One 15 75. PMID: 25886126.

Lasker et al (2013) The sGC activator BAY 60-2770 has potent erectile activity in the rat. Am J Physiol Heart Circ Physiol 304 H1670. PMID: 23585129.

Seto et al (2013) Acute simvastatin inhibits K ATP channels of porcine coronary artery myocytes. Am J Physiol Heart Circ Physiol 8 e66404. PMID: 23799098.

Institóris et al (2011) Impaired vascular responses of insulin-resistant rats after mild subarachnoid hemorrhage. PLoS One 300 H2080. PMID: 21421821.

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Keywords: Cromakalim, supplier, KATP, channel, openers, Potassium, KIR, Kir6, Channels, Inward, Rectifier, K+, BRL34915, Tocris Bioscience, Inward Rectifier Potassium (Kir) Channel Activator products

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