Phaclofen

Cat. No. 0178

Phaclofen C9H13ClNO3P [114012-12-3]

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Chemical Name: (RS)-3-Amino-2-(4-chlorophenyl)propylphosphonic acid

Biological Activity

Selective GABAB antagonist. Phosphono analog of GABAB agonist baclofen (Cat. No. 0417).

Technical Data

M.Wt:
249.63
Formula:
C9H13ClNO3P
Solubility:
Soluble to 25 mM in 1eq. NaOH
Purity:
>97 %
Storage:
Store at RT
CAS No:
114012-12-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Hasuo and Gallagher (1988) Comparison of antagonism by phaclofen of baclofen induced hyperpolarization and synaptically mediated late hyperpolarizing potentials recorded intracellularly from rat dorsolateral septal neurons. Neurosci.Lett. 86 77. PMID: 3362432.

Karlsson et al (1988) Phaclofen: a GABAB blocker reduced long-duration inhibition in the neocortex. Eur.J.Pharmacol. 148 485. PMID: 2838310.

Kerr et al (1987) Phaclofen: a peripheral and central baclofen antagonist. Brain Res. 405 150. PMID: 3032346.

If you know of a relevant reference for Phaclofen please let us know.

Citations are publications that use Tocris products. Selected citations for Phaclofen include:

Wood et al (2000) The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen. Br J Pharmacol 131 1050. PMID: 11082110.

Do you know of a great paper that uses Phaclofen from Tocris? If so please let us know.

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Keywords: Phaclofen, supplier, selective, GABAB, antagonists, Receptors, Tocris Bioscience, GABAB Receptor Antagonist products

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