Cat. No. 0178
Chemical Name: (RS)-3-Amino-2-(4-chlorophenyl)prop
Biological ActivitySelective GABAB antagonist. Phosphono analog of GABAB agonist baclofen (Cat. No. 0417).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Hasuo and Gallagher (1988) Comparison of antagonism by phaclofen of baclofen induced hyperpolarization and synaptically mediated late hyperpolarizing potentials recorded intracellularly from rat dorsolateral septal neurons. Neurosci.Lett. 86 77. PMID: 3362432.
Karlsson et al (1988) Phaclofen: a GABAB blocker reduced long-duration inhibition in the neocortex. Eur.J.Pharmacol. 148 485. PMID: 2838310.
Kerr et al (1987) Phaclofen: a peripheral and central baclofen antagonist. Brain Res. 405 150. PMID: 3032346.
If you know of a relevant reference for Phaclofen please let us know.
Citations are publications that use Tocris products. Selected citations for Phaclofen include:
Wood et al (2000) The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen. Br J Pharmacol 131 1050. PMID: 11082110.
Do you know of a great paper that uses Phaclofen from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Phaclofen, supplier, selective, GABAB, antagonists, Receptors, Tocris Bioscience, GABAB Receptor Antagonist products
Find multiple products by catalog number
New Products in this Area
Irreversible P2Y12 antagonist; antiplatelet and orally activeBigLEN (rat)
Potent GPR171 agonistBigLEN (mouse)
P2Y1 allosteric antagonistAC 265347
CaSR biased allosteric modulator7α,25-Dihydroxycholesterol
Highly potent GPR183 (EBI2) agonistAR-C 69931 tetrasodium salt
Highly potent P2Y12 antagonistFTY 720
Potent S1P receptor agonist; also immunosuppressantCinacalcet hydrochloride
Calcium-sensing receptor (CaSR) allosteric agonist; also CYP2D2 inhibitor and Ca2+ channel blocker; orally bioavailableAMG 837 hemicalcium salt
Potent free fatty acid receptor 1 (FFA1/GPR40) partial agonistUMB 68
GHB receptor ligand
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.