Parthenolide

Cat. No. 0610

Parthenolide C15H20O3 [20554-84-1]

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Chemical Name: [1aR-(1aR*,4E,7aS*,10aS*,-10bR*)]-2,3-6,7,7a,8,10a,10b-Octahydro-1a,5-dimethyl-8-methyleneoxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one

Biological Activity

The active principle of feverfew (Chrysanthemum parthenium), widely used as a herbal remedy for arthritis and migraine and as a febrifuge. Antisecretory, anti-inflammatory and spasmolytic; inhibits the release of 5-HT from blood platelets. Also inhibits generation of leukotriene B4 and thromboxane B2.

Technical Data

M.Wt:
248.32
Formula:
C15H20O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at +4°C
CAS No:
20554-84-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Sumner et al (1992) Inhibition of 5-lipoxygenase and cyclo-oxygenase in leukocytes by feverfew. Involvement of sesquiterpene lactones and other components. Biochem.Pharmacol. 43 2313. PMID: 1319159.

Groenewegen and Heptinstall (1990) A comparison of the effects of an extract of feverfew and parthenolide, a component of feverfew, on human platelet activity in vitro. J.Pharm.Pharmacol. 42 553. PMID: 1981582.

Murphy et al (1988) Randomized double-blind placebo controlled trial of feverfew in migraine prevention. Lancet 2 189. PMID: 2899663.

Heptinstall et al (1986) Compounds extracted from feverfew that have anti-secretory activity contain an α-methylene butyrolactone unit. J.Pharm.Pharmacol. 38 709. PMID: 2877077.

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Citations are publications that use Tocris products. Selected citations for Parthenolide include:

Lee et al (2016) Mincle-mediated translational regulation is required for strong nitric oxide production and inflammation resolution. Anesth Analg 7 11322. PMID: 27089465.

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Keywords: Parthenolide, supplier, 5-HT, release, inhibitors, inhibits, Serotonin, 5-Hydroxytryptamine, Receptors, 5-HT3, feverfew, Tocris Bioscience, 5-HT-Related products

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