Palmitoylethanolamide

Cat. No. 0879

Palmitoylethanolamide C18H37NO2 [544-31-0]

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Alternative Name: PEA

Chemical Name: N-(2-Hydroxyethyl)hexadecanamide

Biological Activity

Endogenous lipid that acts as a selective GPR55 agonist (EC50 values are 4, 19 800 and > 30 000 nM at GPR55, CB2 and CB1 receptors respectively). Substrate for fatty acid amide hydrolase (FAAH) and PEA-preferring acid amidase (PAA) and exhibits antinociceptive and anticonvulsant in vivo. Directly activates PPARα (EC50 = 3 μM) producing robust anti-inflammatory actions.

Technical Data

M.Wt:
299.5
Formula:
C18H37NO2
Solubility:
Soluble to 20 mM in DMSO and to 25 mM in ethanol
Storage:
Store at RT
CAS No:
544-31-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

Ryberg et al (2007) The orphan receptor GPR55 is a novel cannabinoid receptor. Br.J.Pharmacol. 152 1092. PMID: 17876302.

Lo Verme et al (2005) The search for the palmitoylethanolamide receptor. Life Sci. 77 1685. PMID: 15963531.

Re et al (2005) Palmitoylethanolamide, endocannabinoids and related cannabimimetic compounds in protection against tissue inflammation and pain: potential use in companion animals. Vet.J. 173 21. PMID: 16324856.

Lambert et al (2002) The palmitoylethanolamide family: a new class of anti-inflammatory agents? Curr.Med.Chem. 9 663. PMID: 11945130.

Lambert et al (2001) Anticonvulsant activity of N-palmitoylethanolamide, a putative endocannabinoid, in mice. Epilepsia 42 321. PMID: 11442148.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Palmitoylethanolamide include:

Ho et al (2008) 'Entourage' effects of N-palmitoylethanolamide and N-oleoylethanolamide on vasorelaxation to anandamide occur through TRPV1 receptors. Br J Pharmacol 155 837. PMID: 18695637.

Melis et al (2008) Endogenous fatty acid ethanolamides suppress nicotine-induced activation of mesolimbic dopamine neurons through nuclear receptors. J Neurosci 28 13985. PMID: 19091987.

Do you know of a great paper that uses Palmitoylethanolamide from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: Palmitoylethanolamide, supplier, Endogenous, lipid, PPARα, PPARalpha, agonists, activity, Selective, GPR55, FAAH, PAA, PEA-preferring, acid, amidase, Peroxisome, Proliferator-activating, Receptors, PPAR, Cannabinoid, Anandamide, Fatty, Acid, Amide, Hydrolases, Tocris Bioscience, GPR55 Agonist products

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