Cat. No. 1199
Chemical Name: 8,8'-[Carbonylbis(imino-4,1-phenylen
Biological ActivityA potent and selective P2X1 antagonist (IC50 = 19 nM). Displays good selectivity over P2X2,(IC50 = 0.76 μM), P2X3 (IC50 = 1.62μM), P2X4 (IC50 > 300 μM), P2Y receptors and ecto-nucleotidases.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Klapperstuck et al (2000) Antagonism by the suramin analogue NF 279 on human P2X1 and P2X7 receptors. Eur.J.Pharmacol. 387 245. PMID: 10650169.
Rettinger et al (2000) The suramin analogue NF279 is a novel and potent antagonist selective for the P2X1 receptor. Neuropharmacology 39 2044. PMID: 10963748.
Damer et al (1998) NF279: a novel potent and selective antagonist of P2X receptor-mediated responses. Eur.J.Pharmacol. 350 R5. PMID: 9683026.
If you know of a relevant reference for NF 279 please let us know.
Citations are publications that use Tocris products. Selected citations for NF 279 include:
Aliagas et al (2014) High expression of ecto-nucleotidases CD39 and CD73 in human endometrial tumors. PLoS One 2014 509027. PMID: 24707115.
Aliagas et al (2013) Reduced striatal ecto-nucleotidase activity in schizophrenia patients supports the "adenosine hypothesis". Purinergic Signal 9 599. PMID: 23771238.
Hazleton et al (2012) Purinergic receptors are required for HIV-1 infection of primary human macrophages. J Immunol 188 4488. PMID: 22450808.
Ibáñez et al (2012) A high throughput scintillation proximity imaging assay for protein methyltransferases. Comb Chem High Throughput Screen 15 359. PMID: 22256970.
Donnelly-Roberts et al (2009) Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors. Br J Pharmacol 157 1203. PMID: 19558545.
Luke and Hexum (2008) UTP and ATP increase extracellular signal-regulated kinase 1/2 phosphorylation in bovine chromaffin cells through epidermal growth factor receptor transactivation. Mediators Inflamm 4 323. PMID: 18777108.
Kennedy et al (2007) Identification of atropine- and P2X1 receptor antagonist-resistant, neurogenic contractions of the urinary bladder. J Neurosci 27 845. PMID: 17251425.
Inscho et al (2003) Physiological role for P2X1 receptors in renal microvascular autoregulatory behavior. J Clin Invest 112 1895. PMID: 14679185.
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Keywords: NF 279, supplier, Potent, selective, P2X1, antagonists, Receptors, Purinergic, purinoceptors, NF279, Tocris Bioscience, Purinergic (P2X) Receptor Antagonist products
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