Cat. No. 0934
Alternative Name: NE 19550
Chemical Name: N-Vanillyloleoylamide
Biological ActivityPotent vanilloid receptor agonist (pEC50 values are 8.1 and 7.7 at rat and human VR1 receptors respectively). Also blocks anandamide uptake (IC50 = 9 μM) and may bind to CB1 cannabinoid receptors. Antinociceptive following systemic administration. Also available as part of the Vanilloid TRPV1 Receptor Tocriset™.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Ralevic et al (2001) Cannabinoid activation of recombinant and endogenous vanilloid receptors. Eur.J.Pharmacol. 424 211. PMID: 11672565.
Di Marzo et al (1998) Interactions between synthetic vanilloids and the endogenous cannabinoid system. FEBS Lett. 436 449. PMID: 9801167.
Janusz et al (1993) Vanilloids. 1. Analogs of capsaicin with antinociceptive and antiinflammatory activity. J.Med.Chem. 36 2595. PMID: 8410971.
Dray et al (1990) NE-19550 and NE-21610, antinociceptive capsaicin analogues: studies on nociceptive fibres of the neonatal rat tail in vitro. Eur.J.Pharmacol. 181 289. PMID: 2384136.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses Olvanil from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Olvanil, supplier, Potent, vanilloid, agonists, Receptors, VR1, TRPV, TRP, Channels, Transient, Receptor, Potential, NE19550, Tocris Bioscience, TRPV Agonist products
Find multiple products by catalog number
New Products in this Area
Selective TRPM8 blockerM 084 hydrochloride
TRPC4/5 channel blocker; antidepressant and anxiolyticA 425619
Potent TRPV1 antagonistRN 9893 hydrochloride
Potent and selective TRPV4 antagonist
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.