Cat. No. 0880

ODQ C9H5N3O2 [41443-28-1]

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Chemical Name: 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one

Biological Activity

A potent and selective inhibitor of NO-sensitive guanylyl cyclase.

Technical Data

Soluble to 20 mM in ethanol with gentle warming and to 100 mM in DMSO
>99 %
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Hwang et al (1998) Comparison of two soluble guanylyl cyclase inhibitors, methylene blue and ODQ, on sodium nitroprusside-induced relaxation in guinea-pig trachea. Br.J.Pharmacol. 125 1158. PMID: 9863642.

Fedele et al (1996) In vivo microdialysis study of a specific inhibitor of soluble guanylyl cyclase on the glutamate receptor/nitric oxide/cyclic GMP pathway. Br.J.Pharmacol. 119 590. PMID: 8894183.

Boulton et al (1995) Nitric oxide-dependent long-term potentiation is blocked by a specific inhibitor of soluble guanylyl cyclase. Neuroscience 69 699. PMID: 8596640.

Garthwaite et al (1995) Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one. Mol.Pharmacol. 48 184. PMID: 7544433.

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Citations are publications that use Tocris products. Selected citations for ODQ include:

Yuan et al (2015) Protein kinase G-regulated production of H2S governs oxygen sensing. Sci Signal 8 ra37. PMID: 25900831.

Bice et al (2014) NO-independent stimulation or activation of soluble guanylyl cyclase during early reperfusion limits infarct size. Cardiovasc Res 101 220. PMID: 24259501.

Ho et al (2013) Caffeic acid phenethyl amide improves glucose homeostasis and attenuates the progression of vascular dysfunction in Streptozotocin-induced diabetic rats. Cardiovasc Diabetol 12 99. PMID: 23829275.

Tseng et al (2011) Inhibition of striatal soluble guanylyl cyclase-cGMP signaling reverses basal ganglia dysfunction and akinesia in experimental parkinsonism. PLoS One 6 e27187. PMID: 22073284.

Yoo et al (2010) Inhibition of hypoxic pulmonary vasoconstriction of rats by carbon monoxide. J Korean Med Sci 25 1411. PMID: 20890419.

Chester et al (2009) Cinaciguat, a soluble guanylate cyclase activator, causes potent and sustained pulmonary vasodilation in the ovine fetus. Am J Physiol Lung Cell Mol Physiol 297 L318. PMID: 19465519.

Hoffmann et al (2009) Distinct molecular requirements for activation or stabilization of soluble guanylyl cyclase upon haem oxidation-induced degradation. Br J Pharmacol 157 781. PMID: 19466990.

Anselm et al (2007) Grape juice causes endothelium-dependent relaxation via a redox-sensitive Src- and Akt-dependent activation of eNOS. Cardiovasc Res 73 404. PMID: 16962569.

Dalsgaard et al (2007) Nitrite-dependent vasodilation is facilitated by hypoxia and is independent of known NO-generating nitrite reductase activities. Am J Physiol Heart Circ Physiol 292 H3072. PMID: 17307993.

Newman et al (2007) Endocannabinoids mediate muscarine-induced synaptic depression at the vertebrate neuromuscular junction. Eur J Neurosci 25 1619. PMID: 17408433.

Sachs et al (2004) Peripheral analgesic blockade of hypernociception: activation of arginine/NO/cGMP/protein kinase G/ATP-sensitive K+ channel pathway. Proc Natl Acad Sci U S A 101 3680. PMID: 14990791.

Dick et al (2000) Investigation of the interaction between nitric oxide and vasoactive intestinal polypeptide in the guinea-pig gastric fundus. Br J Pharmacol 129 751. PMID: 10683200.

Aszódi et al (1999) The vasodilator-stimulated phosphoprotein (VASP) is involved in cGMP- and cAMP-mediated inhibition of agonist-induced platelet aggregation, but is dispensable for smooth muscle function. EMBO J 18 37. PMID: 9878048.

Cogolludo et al (1999) Effects of nicorandil as compared to mixtures of sodium nitroprusside and levcromakalim in isolated rat aorta. Br J Pharmacol 126 1025. PMID: 10193784.

Pérez-Vizcaíno et al (1999) Vasodilator effects of sodium nitroprusside, levcromakalim and their combination in isolated rat aorta. Br J Pharmacol 128 1419. PMID: 10602320.

Villarroya et al (1999) PF9404C, a new slow NO donor with beta receptor blocking properties. Br J Pharmacol 128 1713. PMID: 10588927.

Prieto et al (1998) Contribution of K+ channels and ouabain-sensitive mechanisms to the endothelium-dependent relaxations of horse penile small arteries. Br J Pharmacol 123 1609. PMID: 9605568.

Ruiz and Tejerina (1998) Relaxant effects of L-citrulline in rabbit vascular smooth muscle. Br J Pharmacol 125 186. PMID: 9776359.

Do you know of a great paper that uses ODQ from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: ODQ, supplier, Selective, inhibitors, inhibits, NO-sensitive, guanylyl, cyclases, sGC, Nitric, Oxide, Signaling, Signalling, Tocris Bioscience, Other Nitric Oxide Inhibitor products

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