ODQ

Cat. No. 0880

ODQ C9H5N3O2 [41443-28-1]

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Chemical Name: 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one

Biological Activity

A potent and selective inhibitor of NO-sensitive guanylyl cyclase.

Technical Data

M.Wt:
187.16
Formula:
C9H5N3O2
Solubility:
Soluble to 20 mM in ethanol with gentle warming and to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
41443-28-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Hwang et al (1998) Comparison of two soluble guanylyl cyclase inhibitors, methylene blue and ODQ, on sodium nitroprusside-induced relaxation in guinea-pig trachea. Br.J.Pharmacol. 125 1158. PMID: 9863642.

Fedele et al (1996) In vivo microdialysis study of a specific inhibitor of soluble guanylyl cyclase on the glutamate receptor/nitric oxide/cyclic GMP pathway. Br.J.Pharmacol. 119 590. PMID: 8894183.

Boulton et al (1995) Nitric oxide-dependent long-term potentiation is blocked by a specific inhibitor of soluble guanylyl cyclase. Neuroscience 69 699. PMID: 8596640.

Garthwaite et al (1995) Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one. Mol.Pharmacol. 48 184. PMID: 7544433.

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Citations are publications that use Tocris products. Selected citations for ODQ include:

Galdino et al (2015) Central release of nitric oxide mediates antinociception induced by aerobic exercise. Proc Natl Acad Sci U S A 48 790. PMID: 25517916.

Garthwaite et al (2015) Nitric oxide targets oligodendrocytes and promotes their morphological differentiation. Braz J Med Biol Res 63 383. PMID: 25327839.

Padovan-Neto et al (2015) Facilitation of corticostriatal transmission following pharmacological inhibition of striatal phosphodiesterase 10A: role of nitric oxide-soluble guanylyl cyclase-cGMP signaling pathways. Mol Cell Neurosci 35 5781. PMID: 25855188.

Wallace et al (2015) Regulation of nerve-evoked contractions of rabbit vas deferens by acetylcholine. Proc Natl Acad Sci U S A 3. PMID: 26359240.

Yuan et al (2015) Protein kinase G-regulated production of H2S governs oxygen sensing. Sci Signal 8 ra37. PMID: 25900831.

Bice et al (2014) NO-independent stimulation or activation of soluble guanylyl cyclase during early reperfusion limits infarct size. Cardiovasc Res 101 220. PMID: 24259501.

Ho et al (2013) Caffeic acid phenethyl amide improves glucose homeostasis and attenuates the progression of vascular dysfunction in Streptozotocin-induced diabetic rats. Cardiovasc Diabetol 12 99. PMID: 23829275.

Fakira et al (2012) Purkinje cell dysfunction and delayed death in plasma membrane calcium ATPase 2-heterozygous mice. Glia 51 22. PMID: 22789621.

Chester et al (2011) Cinaciguat, a soluble guanylate cyclase activator, augments cGMP after oxidative stress and causes pulmonary vasodilation in neonatal pulmonary hypertension. J Neurosci 301 L755. PMID: 21856817.

Harnek et al (2011) Intimal hyperplasia in balloon dilated coronary arteries is reduced by local delivery of the NO donor, SIN-1 via a cGMP-dependent pathway. Exp Mol Med 11 30. PMID: 21663688.

Tseng et al (2011) Inhibition of striatal soluble guanylyl cyclase-cGMP signaling reverses basal ganglia dysfunction and akinesia in experimental parkinsonism. PLoS One 6 e27187. PMID: 22073284.

Yoo et al (2010) Inhibition of hypoxic pulmonary vasoconstriction of rats by carbon monoxide. J Korean Med Sci 25 1411. PMID: 20890419.

Chester et al (2009) Cinaciguat, a soluble guanylate cyclase activator, causes potent and sustained pulmonary vasodilation in the ovine fetus. Am J Physiol Lung Cell Mol Physiol 297 L318. PMID: 19465519.

Hoffmann et al (2009) Distinct molecular requirements for activation or stabilization of soluble guanylyl cyclase upon haem oxidation-induced degradation. Br J Pharmacol 157 781. PMID: 19466990.

Anselm et al (2007) Grape juice causes endothelium-dependent relaxation via a redox-sensitive Src- and Akt-dependent activation of eNOS. Cardiovasc Res 73 404. PMID: 16962569.

Dalsgaard et al (2007) Nitrite-dependent vasodilation is facilitated by hypoxia and is independent of known NO-generating nitrite reductase activities. Am J Physiol Heart Circ Physiol 292 H3072. PMID: 17307993.

Newman et al (2007) Endocannabinoids mediate muscarine-induced synaptic depression at the vertebrate neuromuscular junction. Eur J Neurosci 25 1619. PMID: 17408433.

McNeish et al (2006) Evidence for involvement of both IKCa and SKCa channels in hyperpolarizing responses of the rat middle cerebral artery. BMC Cardiovasc Disord 37 1277. PMID: 16556879.

Namkoong et al (2005) Prostaglandin E2 stimulates angiogenesis by activating the nitric oxide/cGMP pathway in human umbilical vein endothelial cells. J Pharmacol Exp Ther 37 588. PMID: 16391520.

Sachs et al (2004) Peripheral analgesic blockade of hypernociception: activation of arginine/NO/cGMP/protein kinase G/ATP-sensitive K+ channel pathway. Proc Natl Acad Sci U S A 101 3680. PMID: 14990791.

Cirino et al (2003) Involvement of β 3-adrenergic receptor activation via cyclic GMP- but not NO-dependent mechanisms in human corpus cavernosum function. Am J Physiol Lung Cell Mol Physiol 100 5531. PMID: 12707413.

Casado et al (2000) Presynaptic N-methyl-D-aspartate receptors at the parallel fiber-Purkinje cell synapse. Stroke 97 11593. PMID: 11016958.

Dick et al (2000) Investigation of the interaction between nitric oxide and vasoactive intestinal polypeptide in the guinea-pig gastric fundus. Br J Pharmacol 129 751. PMID: 10683200.

Hedlund et al (2000) Erectile dysfunction in cyclic GMP-dependent kinase I-deficient mice. Physiol Rep 97 2349. PMID: 10688876.

Aszódi et al (1999) The vasodilator-stimulated phosphoprotein (VASP) is involved in cGMP- and cAMP-mediated inhibition of agonist-induced platelet aggregation, but is dispensable for smooth muscle function. EMBO J 18 37. PMID: 9878048.

Cogolludo et al (1999) Effects of nicorandil as compared to mixtures of sodium nitroprusside and levcromakalim in isolated rat aorta. Br J Pharmacol 126 1025. PMID: 10193784.

Pérez-Vizcaíno et al (1999) Vasodilator effects of sodium nitroprusside, levcromakalim and their combination in isolated rat aorta. Br J Pharmacol 128 1419. PMID: 10602320.

Villarroya et al (1999) PF9404C, a new slow NO donor with beta receptor blocking properties. Br J Pharmacol 128 1713. PMID: 10588927.

Prieto et al (1998) Contribution of K+ channels and ouabain-sensitive mechanisms to the endothelium-dependent relaxations of horse penile small arteries. Br J Pharmacol 123 1609. PMID: 9605568.

Ruiz and Tejerina (1998) Relaxant effects of L-citrulline in rabbit vascular smooth muscle. Br J Pharmacol 125 186. PMID: 9776359.

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Keywords: ODQ, supplier, Selective, inhibitors, inhibits, NO-sensitive, guanylyl, cyclases, sGC, Nitric, Oxide, Signaling, Signalling, Tocris Bioscience, Other Nitric Oxide Inhibitor products

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