BYK 191023 dihydrochloride

Cat. No. 2866

BYK 191023 dihydrochloride C14H14N4O.2HCl [1216722-25-6]

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Chemical Name: 2-[2-(4-Methoxy-2-pyridinyl)ethyl]-1H-imidazo[4,5-b]pyridine dihydrochloride

Biological Activity

Potent and selective inhibitor of inducible nitric oxide synthase (iNOS) (IC50 values are 86, 17000, 162000 nM for iNOS, nNOS and eNOS respectively). Acts in an NADPH- and time-dependent manner. Active in vivo, reverses pathological hypotension in the rodent endotoxin model.

Licensing Information

Sold with the permission of Nycomed

Technical Data

M.Wt:
327.21
Formula:
C14H14N4O.2HCl
Solubility:
Soluble to 100 mM in water
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
1216722-25-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Tiso et al (2008) BYK191023 (2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine) is an NADPH- and time-dependent irreversible inhibitor of inducible nitric-oxide synthase. Mol.Pharmacol. 72 1244.

Lehner et al (2006) In vivo characterisation of the novel imidazopyridine BYK191023 2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine, a potent and highly selective inhibitor of inducible nitric-oxide synthase. J.Pharmacol.Exp.Ther. 317 181. PMID: 16368897.

Strub et al (2006) The novel imidazopyridine 2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine (BYK191023) is a highly selective inhibitor of the inducible nitric-oxide synthase. Mol.Pharmacol. 68 328.

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Keywords: BYK 191023 dihydrochloride, supplier, Potent, selective, inhibitors, inhibits, iNOS, Nitric, Oxide, Signaling, Signalling, Inducible, NO, Synthases, BYK191023, dihydrochloride, Tocris Bioscience, iNOS Inhibitor products

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