Cat. No. 0606
Chemical Name: 4-(4-Octadecylphenyl)-4-oxobutenoic
Biological ActivityA potent inhibitor of phospholipase A2 (IC50 = 70 nM). Reduces bronchospasm in guinea pigs in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Kohler et al (1992) Phospholipase A2 inhibition by alkylbenzoyl acrylic acids. Biochem.Pharmacol. 44 805. PMID: 1324685.
Kohler et al (1991) Phospholipase-A2 inhibition by alkylbenzoyl acrylic acids. Agents Actions 32 70. PMID: 2058477.
Madi et al (1991) Allergen-induced bronchospasm in passively sensitized guinea-pigs - influence of new substances in comparison to reference compounds. Agents Actions 32 144. PMID: 2058463.
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Citations are publications that use Tocris products. Selected citations for OBAA include:
Bianca et al (2010) Hydrogen sulphide induces mouse paw oedema through activation of phospholipase A2. Nat Commun 161 1835. PMID: 20825409.
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Keywords: OBAA, supplier, Phospholipases, A2, inhibitors, inhibits, PLA, sPLA2, Esterases, Tocris Bioscience, Phospholipase Inhibitor products