Cat. No. 0606

OBAA C28H44O3 [221632-26-4]

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Chemical Name: 4-(4-Octadecylphenyl)-4-oxobutenoic acid

Biological Activity

A potent inhibitor of phospholipase A2 (IC50 = 70 nM). Reduces bronchospasm in guinea pigs in vivo.

Technical Data

Soluble to 10 mM in DMSO with gentle warming
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Kohler et al (1992) Phospholipase A2 inhibition by alkylbenzoyl acrylic acids. Biochem.Pharmacol. 44 805. PMID: 1324685.

Kohler et al (1991) Phospholipase-A2 inhibition by alkylbenzoyl acrylic acids. Agents Actions 32 70. PMID: 2058477.

Madi et al (1991) Allergen-induced bronchospasm in passively sensitized guinea-pigs - influence of new substances in comparison to reference compounds. Agents Actions 32 144. PMID: 2058463.

If you know of a relevant reference for OBAA please let us know.

Citations are publications that use Tocris products. Selected citations for OBAA include:

Bianca et al (2010) Hydrogen sulphide induces mouse paw oedema through activation of phospholipase A2. Nat Commun 161 1835. PMID: 20825409.

Do you know of a great paper that uses OBAA from Tocris? If so please let us know.

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Keywords: OBAA, supplier, Phospholipases, A2, inhibitors, inhibits, PLA, sPLA2, Esterases, Tocris Bioscience, Phospholipase Inhibitor products

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