Oleamide

Cat. No. 0878

Oleamide C18H35NO [301-02-0]

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Chemical Name: cis-9-Octadecenamide

Biological Activity

Endogenous sleep-inducing lipid. Acts as an agonist at the CB1 cannabinoid receptor (EC50 = 1.64 μM). Also appears to potentiate the actions of 5-HT on 5-HT2A and 2C receptors, and act via an allosteric regulatory site on 5-HT7 receptors.

Technical Data

M.Wt:
281.48
Formula:
C18H35NO
Solubility:
Soluble to 100 mM in ethanol and to 50 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
301-02-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Leggett et al (2004) Oleamide is a selective endogenous agonist of rat and human CB1 cannabinoid receptors. Br.J.Pharmacol. 141 253. PMID: 14707029.

Hedlund et al (1999) Allosteric regulation by oleamide of the binding properties of 5-hydroxytryptamine7 receptors. Biochem.Pharmacol. 58 1807. PMID: 10571256.

Huidobro-Toro and Harris (1996) Brain lipids that induce sleep are novel modulators of 5-hydroxytryptamine receptors. Proc.Natl.Acad.Sci.U.S.A. 93 8078. PMID: 8755606.

Cravatt et al (1995) Chemical characterisation of a family of brain lipids that induces sleep. Science 268 1506. PMID: 7770779.

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Keywords: Oleamide, supplier, Sleep-inducing, brain, lipid, Potentiator, 5-HT2A, 5-HT2C, receptors, CB1, agonists, Lipid, Metabolism, Serotonin, 5-Hydroxytryptamine, Cannabinoid, cb1r, Tocris Bioscience, Other Lipid Metabolism products

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