PMPA (NAALADase inhibitor)
Cat. No. 1380
Chemical Name: 2-(Phosphonomethyl)pentane-1,5-dioi
Biological ActivityHighly potent and selective inhibitor of glutamate carboxypeptidase 2 (GCP II/N-acetylated α-linked dipeptidase/NAALADase) with a Ki value of 275 pM. Neuroprotective; protects against glutamate-mediated motor neuron degeneration and reduces volume of injury following middle cerebral artery occlusion (MCAO).
Licensing InformationSold with the permission of AstraZeneca Ltd.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Rahn et al (2012) Inhibition of glutamate carboxypeptidase II (GCPII) activity as a treatment for cognitive impairment in multiple sclerosis. Proc.Natl.Acad.Sci.U S A (Epub ahead of print]. PMID: 23169655.
Thomas et al (2003) NAALADase inhibition protects motor neurons against chronic glutamate toxicity. Eur.J.Pharmacol. 471 177. PMID: 12826236.
Slusher et al (1999) Selective inhibition of NAALADase, which converts NAAG to glutamate, reduces ischemic brain injury. Nat.Med. 5 1396. PMID: 10581082.
Jackson et al (1996) Design, synthesis, and biological activity of a potent inhibitor of the neuropeptidase N-acetylated α-linked acidic dipeptidase. J.Med.Chem. 39 619. PMID: 8558536.
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Keywords: PMPA (NAALADase inhibitor), supplier, potent, selective, NAALADase, GCP, II, inhibitors, inhibits, Carboxypeptidase, NAAG, Peptidase, Proteinases, Proteases, AstraZeneca, Tocris Bioscience, Carboxypeptidase Inhibitor products
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