PMPA (NAALADase inhibitor)

Cat. No. 1380

PMPA (NAALADase inhibitor) C6H11O7P [173039-10-6]

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Chemical Name: 2-(Phosphonomethyl)pentane-1,5-dioic acid

Biological Activity

Highly potent and selective inhibitor of  glutamate carboxypeptidase 2 (GCP II/N-acetylated α-linked dipeptidase/NAALADase) with a Ki value of 275 pM. Neuroprotective; protects against glutamate-mediated motor neuron degeneration and reduces volume of injury following middle cerebral artery occlusion (MCAO).

Licensing Information

Sold with the permission of AstraZeneca Ltd.

Technical Data

M.Wt:
226.12
Formula:
C6H11O7P
Solubility:
Soluble to 100 mM in water
Storage:
Desiccate at RT
CAS No:
173039-10-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Rahn et al (2012) Inhibition of glutamate carboxypeptidase II (GCPII) activity as a treatment for cognitive impairment in multiple sclerosis. Proc.Natl.Acad.Sci.U S A (Epub ahead of print]. PMID: 23169655.

Thomas et al (2003) NAALADase inhibition protects motor neurons against chronic glutamate toxicity. Eur.J.Pharmacol. 471 177. PMID: 12826236.

Slusher et al (1999) Selective inhibition of NAALADase, which converts NAAG to glutamate, reduces ischemic brain injury. Nat.Med. 5 1396. PMID: 10581082.

Jackson et al (1996) Design, synthesis, and biological activity of a potent inhibitor of the neuropeptidase N-acetylated α-linked acidic dipeptidase. J.Med.Chem. 39 619. PMID: 8558536.

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Citations are publications that use Tocris products.

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Keywords: PMPA (NAALADase inhibitor), supplier, potent, selective, NAALADase, GCP, II, inhibitors, inhibits, Carboxypeptidase, NAAG, Peptidase, Proteinases, Proteases, AstraZeneca, Tocris Bioscience, Carboxypeptidase Inhibitor products

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