Cat. No. 0593
Chemical Name: 5-Nitro-2-(3-phenylpropylamino)benz
Biological ActivityInhibits calcium-sensitive chloride currents (10 μM). Putative GPR35 agonist.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Taniguchi et al (2008) 5-nitro-2-(3-phenylpropylamino)benzoic acid is a GPR35 agonist Pharmacology 82 245. PMID: 18818509.
Kirkup et al (1996) Investigation of the effects of 5-nitro-2-(3-phenylpropylamino)-benzoic acid (NPPB) on membrane currents in rat portal vein. Br.J.Pharmacol. 117 175. PMID: 8825360.
Keeling et al (1991) Effects of NPPB (5-nitro-1-(3-phenylpropylamino)benzoic acid on chloride transport in intestinal tissues and the T84 cell line. Biochim.Biophys.Acta 115 42. PMID: 1720331.
Wangemann et al (1986) Cl--channel blockers in the thick ascending limb of the loop of Henle. Structure-activity relationship. Pflugers Arch. 407 S128. PMID: 2434915.
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Citations are publications that use Tocris products. Selected citations for NPPB include:
Silverman et al (2008) Probenecid, a gout remedy, inhibits pannexin 1 channels. Am J Physiol Cell Physiol 295 C761. PMID: 18596212.
Li et al (2005) Hemolysis of erythrocytes by granulysin-derived peptides but not by granulysin. Antimicrob Agents Chemother 49 388. PMID: 15616319.
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Keywords: NPPB, supplier, Chloride, channel, blockers, Cl-, Channels, Tocris Bioscience, Chloride Channel Blocker products