Cat. No. 0593

NPPB C16H16N2O4 [107254-86-4]

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Chemical Name: 5-Nitro-2-(3-phenylpropylamino)benzoic acid

Biological Activity

Inhibits calcium-sensitive chloride currents (10 μM). Putative GPR35 agonist.

Technical Data

Soluble to 100 mM in DMSO and to 20 mM in ethanol
>99 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

Taniguchi et al (2008) 5-nitro-2-(3-phenylpropylamino)benzoic acid is a GPR35 agonist Pharmacology 82 245. PMID: 18818509.

Kirkup et al (1996) Investigation of the effects of 5-nitro-2-(3-phenylpropylamino)-benzoic acid (NPPB) on membrane currents in rat portal vein. Br.J.Pharmacol. 117 175. PMID: 8825360.

Keeling et al (1991) Effects of NPPB (5-nitro-1-(3-phenylpropylamino)benzoic acid on chloride transport in intestinal tissues and the T84 cell line. Biochim.Biophys.Acta 115 42. PMID: 1720331.

Wangemann et al (1986) Cl--channel blockers in the thick ascending limb of the loop of Henle. Structure-activity relationship. Pflugers Arch. 407 S128. PMID: 2434915.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for NPPB include:

Morethson (2015) Extracellular fluid flow and chloride content modulate H(+) transport by osteoclasts. Cell Death Dis 16 20. PMID: 26271334.

Grant et al (2013) Ionic currents of human trabecular meshwork cells from control and glaucoma subjects. Biol Proced Online 246 167. PMID: 23135060.

Harper and Poole (2013) Chloride channels are necessary for full platelet phosphatidylserine exposure and procoagulant activity. J Membr Biol 4 e969. PMID: 24357800.

Silverman et al (2008) Probenecid, a gout remedy, inhibits pannexin 1 channels. Am J Physiol Cell Physiol 295 C761. PMID: 18596212.

Li et al (2005) Hemolysis of erythrocytes by granulysin-derived peptides but not by granulysin. Antimicrob Agents Chemother 49 388. PMID: 15616319.

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Keywords: NPPB, supplier, Chloride, channel, blockers, Cl-, Channels, Tocris Bioscience, Chloride Channel Blocker products

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