Cat. No. 0901
Biological Activity5-HT1B selective agonist, several times more potent than sumatriptan and inactive as a 5-HT1A agonist (Ki at 5-HT1B = 1 nM, selectivity over 5-HT1A > 300-fold). Mimics polysialic acid activity, stimulates neuritogenesis, myelination and Schwann cell migration in vitro.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Loers et al (2013) Nonyloxytryptamine mimics polysialic acid and modulates neuronal and glial functions in cell culture. J.Neurochem. 128 88. PMID: 23957498.
Glennon et al (1996) Binding of O-Alkyl derivatives of serotonin at human 5-HT1Dβ receptors. J.Med.Chem. 39 314. PMID: 8568822.
Glennon et al (1994) 5-(Nonyloxy)tryptamine: a novel high affinity-5-HT1Dβ serotonin receptor agonist. J.Med.Chem. 37 2828. PMID: 8071931.
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Keywords: 5-Nonyloxytryptamine oxalate, supplier, Selective, 5-HT1B, agonists, Serotonin, Receptors, Tocris Bioscience, 5-HT1B Receptor Agonist products