Nociceptin

Cat. No. 0910

Nociceptin Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Leu-Ala-Asn-Gln

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Alternative Name: Orphanin FQ

Biological Activity

Endogenous ligand for the NOP opioid receptor (pKi = 8.6). Has no significant activity at μ, δ or κ opioid receptors (pKi < 6).

Technical Data

M.Wt:
1809
Formula:
C79H129N27O22
Sequence:
FGGFTGARKSARKLANQ
Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
170713-75-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
Select another batch:

Guerrini et al (2000) Structure-activity relationships of nociceptin and related peptides: comparison with dynorphin A. Peptides 21 923. PMID: 10998526.

Henderson and McKnight (1997) The orphan opioid receptor and its endogenous ligand-nociceptin/orphanin FQ. TiPS 18 293. PMID: 9277133.

Meunier et al (1995) Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor. Nature 377 532. PMID: 7566152.

Reinscheid et al (1995) Orphanin FQ: a neuropeptide that activates an opioid like G protein coupled receptor. Science 270 792. PMID: 7481766.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Nociceptin include:

Farrag et al (2015) Modulation of voltage-gated Ca2+ channels by G protein-coupled receptors in celiac-mesenteric ganglion neurons of septic rats. BMC Complement Altern Med 10 e0125566. PMID: 26017846.

Kelly et al (2015) The opioid receptor pharmacology of GSK1521498 compared to other ligands with differential effects on compulsive reward-related behaviours. Neurochem Res 232 305. PMID: 24973897.

McIlwrath and Westlund (2015) Pharmacological attenuation of chronic alcoholic pancreatitis induced hypersensitivity in rats. J Cell Mol Med 21 836. PMID: 25624717.

Wang et al (2015) Buprenorphine-elicited alteration of adenylate cyclase activity in human embryonic kidney 293 cells coexpressing κ-, μ-opioid and nociceptin receptors. Psychopharmacology (Berl) 19 2587. PMID: 26153065.

Popiolek-Barczyk et al (2014) Minocycline enhances the effectiveness of nociceptin/orphanin FQ during neuropathic pain. Biomed Res Int 2014 762930. PMID: 25276817.

Miranda-Morales et al (2013) Participation of the nociceptin/orphanin FQ receptor in ethanol-mediated locomotor activation and ethanol intake in preweanling rats. Behav Brain Res 245 137. PMID: 23439216.

Lee et al (2011) Differential pharmacological actions of methadone and buprenorphine in human embryonic kidney 293 cells coexpressing human μ-opioid and opioid receptor-like 1 receptors. PLoS One 36 2008. PMID: 21671107.

Kokkola et al (2005) S-nitrosothiols modulate G protein-coupled receptor signaling in a reversible and highly receptor-specific manner. BMC Cell Biol 6 21. PMID: 15850493.

Kuzmin et al (2004) Evidence in locomotion test for the functional heterogeneity of ORL-1 receptors. Br J Pharmacol 141 132. PMID: 14662736.

McLeod et al (2001) Nociceptin inhibits cough in the guinea-pig by activation of ORL(1) receptors. World J Gastroenterol 132 1175. PMID: 11250866.

Giuliani and Maggi (1996) Inhibition of tachykinin release from peripheral endings of sensory nerves by nociceptin, a novel opioid peptide. Br J Pharmacol 118 1567. PMID: 8842416.

Do you know of a great paper that uses Nociceptin from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: Nociceptin, supplier, Endogenous, NOP, agonists, Nociceptin, Receptors, ORL1, OP4, Opioid, Tocris Bioscience, NOP Receptor Agonist products

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