7-Nitroindazole

Cat. No. 0602

7-Nitroindazole C7H5N3O2 [2942-42-9]

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Biological Activity

Reversible, competitive and non-selective NOS inhibitor. Monosodium salt 7-NINA (Cat. No. 0800) also available.

Technical Data

M.Wt:
163.14
Formula:
C7H5N3O2
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
>98 %
Storage:
Desiccate at -20°C
CAS No:
2942-42-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Moore and Handy (1997) Selective inhibitors of neuronal nitric oxide synthase - is no NOS really good NOS for the nervous system? TiPS 18 204. PMID: 9226999.

Babbedge et al (1993) Inhibition of rat cerebellar nitric oxide synthase by 7-nitroindazole and related substituted indazoles. Br.J.Pharmacol. 110 225. PMID: 7693279.

Moore et al (1993) 7-nitroindazole, an inhibitor of nitric oxide synthase, exhibits antinociceptive activity in the mouse without increasing blood pressure. Br.J.Pharmacol. 108 296. PMID: 7680591.

Moore et al (1993) Characterisation of the novel nitric oxide synthase inhibitor 7-nitroindazole and related indazoles: antinociceptive and cardiovascular effects. Br.J.Pharmacol. 110 219. PMID: 7693278.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for 7-Nitroindazole include:

Yuan et al (2015) Protein kinase G-regulated production of H2S governs oxygen sensing. Sci Signal 8 ra37. PMID: 25900831.

Do you know of a great paper that uses 7-Nitroindazole from Tocris? If so please let us know.

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Keywords: 7-Nitroindazole, supplier, Non-Selective, NOS, inhibitors, inhibits, Nitric, Oxide, Signaling, Signalling, Synthases, Tocris Bioscience, Non-selective NOS Inhibitor products

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