Cat. No. 0236
Chemical Name: (±)-3-Piperidine carboxylic acid
Biological ActivityGABA uptake inhibitor. IC50 values are 8, 38, 106 and 2370 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
on-line. Please contact Customer Service
Borden et al (1994) Tiagabine, SK&F 89976-A, CI 966, and NNC-711 are selective for the cloned GABA transporter GAT-1. Eur.J.Pharmacol. 269 219. PMID: 7851497.
Krogsgaard-Larsen et al (1981) GABA agonists, antagonists and uptake inhibitors. Design and therapeutic aspects. J.Med.Chem. 24 1377. PMID: 6118436.
Schousboe et al (1979) Effects of GABA analogues of restricted conformation on GABA transport in astrocytes and brain cortex slices and on GABA binding. J.Neurochem. 33 181. PMID: 458448.
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Citations are publications that use Tocris products. Selected citations for (±)-Nipecotic acid include:
Reali et al (2011) GABAergic signalling in a neurogenic niche of the turtle spinal cord. J Physiol 589 5633. PMID: 21911613.
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Keywords: (±)-Nipecotic acid, supplier, GABA, reuptake, inhibitors, inhibits, BGT-1, GAT-1, GAT-2, GAT-3, GAT-4, Transporters, Monoamine, Neurotransmitter, Tocris Bioscience, GABA Inhibitor products
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