Cat. No. 0664

 C6H13N5O4 [2149-70-4]

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Chemical Name: NG-Nitro-L-arginine

Biological Activity

NO synthase inhibitor.

Technical Data

Soluble to 5 mM in water
>99 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Knowles et al (1994) Nitric oxide synthases in mammals. Biochem.J. 298 249. PMID: 7510950.

Dwyer et al (1991) Nitric oxide synthase: irreversible inhibition by L-NG-nitroarginine in brain in vitro and in vivo. Biochem.Biophys.Res.Commun. 176 1136. PMID: 1710109.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for L-NNA include:

Garthwaite et al (2015) Nitric oxide targets oligodendrocytes and promotes their morphological differentiation. J Neurosci 63 383. PMID: 25327839.

Pigott et al (2013) On the selectivity of neuronal NOS inhibitors. Br J Pharmacol 168 1255. PMID: 23072468.

Rodríguez-Muñoz et al (2011) NO-released zinc supports the simultaneous binding of Raf-1 and PKCγ cysteine-rich domains to HINT1 protein at the mu-opioid receptor. Antioxid Redox Signal 14 2413. PMID: 21235400.

Sánchez-Blázquez et al (2010) Mu-opioid receptors transiently activate the Akt-nNOS pathway to produce sustained potentiation of PKC-mediated NMDAR-CaMKII signaling. PLoS One 5 e11278. PMID: 20585660.

Mathison et al (2004) Effects of cannabinoid receptor-2 activation on accelerated gastrointestinal transit in lipopolysaccharide-treated rats. Br J Pharmacol 142 1247. PMID: 15249429.

Do you know of a great paper that uses L-NNA from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: L-NNA, supplier, NOS, inhibitors, inhibits, nNOS, eNOS, iNOS, Non-Selective, Nitric, Oxide, Signaling, Signalling, NO, Synthases, Tocris Bioscience, Non-selective NOS Inhibitor products

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