DOI hydrochloride

Cat. No. 2643

DOI hydrochloride C11H16INO2.HCl [42203-78-1]

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Alternative Name: (±)-2,5-Dimethoxy-4-iodoamphetamine hydrochloride

Chemical Name: 4-Iodo-2,5-dimethoxy-α-methylbenzeneethanamine hydrochloride

Biological Activity

Brain penetrant, mixed 5-HT2A/5-HT2C receptor agonist (Ki values are 0.7, 2.4 and 20 nM for 5-HT2A, 5-HT2C and 5-HT2B receptors respectively). Reduces rapid eye movement (REM) and slow wave sleep and increases waking in the rat. Hallucinogenic agent. Acts via 5-HT2A receptors to inhibit the inflammatory effects of tumor necrosis factor (TNF)-α.

Technical Data

M.Wt:
357.62
Formula:
C11H16INO2.HCl
Solubility:
Soluble to 50 mM in water
Purity:
>98 %
Storage:
Store at RT
CAS No:
42203-78-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Yu et al (2008) Serotonin 5-hydroxytryptamine2A receptor activation suppresses tumor necrosis factor-α-induced inflammation with extraordinary potency. J.Pharmacol.Exp.Ther. 327 316. PMID: 18708586.

Monti and Jantos (2006) Effects of serotonin 5-HT2A/2C receptor agonist DOI and of the selective 5-HT2A or 5-HT2C receptor antagonists EMD 281014 and SB-243213 respectively, on sleep and waking in the rat. Eur.J.Pharmacol. 553 163. PMID: 17059817.

Nelson et al (1999) Comparisons of hallucinogenic phenylisopropylamine binding affinities at cloned human 5-HT2A, 5-HT2B and 5-HT2C receptors. Naunyn-Schmied.Arch.Pharmacol. 359 1.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for DOI hydrochloride include:

Goda et al (2013) Serotonergic hallucinogens differentially modify gamma and high frequency oscillations in the rat nucleus accumbens. Psychopharmacology (Berl) 228 271. PMID: 23525524.

Wood et al (2011) Serotonin, via HTR2 receptors, excites neurons in a cortical-like premotor nucleus necessary for song learning and production. J Neurosci 31 13808. PMID: 21957243.

Do you know of a great paper that uses DOI hydrochloride from Tocris? If so please let us know.

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Keywords: DOI hydrochloride, supplier, Mixed, 5-H2A, 5-HT2C, agonists, serotonin, receptors, 5-hydroxytryptamine, Tocris Bioscience, 5-HT2A Receptor Agonist products

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