Thrombin Receptor Agonist Peptide

Cat. No. 1185

Thrombin Receptor Agonist Peptide Ser-Phe-Leu-Leu-Arg-Asn-Pro-Asn-Asp-Lys-Tyr-Glu-Pro-Phe

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Alternative Name: TRAP

Biological Activity

Agonist at the thrombin receptor; causes platelet aggregation (EC50 = 4 μM) and secretion.

Technical Data

M.Wt:
1739
Formula:
C81H118N20O23
Sequence:
SFLLRNPNDKYEPF
Solubility:
Soluble to 0.90 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
137339-65-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Vassallo et al (1992) Structure-function relationships in the activation of platelet thrombin receptors by receptor-derived peptides. J.Biol.Chem. 267 6081. PMID: 1313429.

Huang et al (1991) 'Thrombin' receptor-directed ligand accounts for activation by thrombin of platelet phospholipase C and accumulation of 3-phosphorylated phosphoinositides. J.Biol.Chem. 266 18435. PMID: 1655750.

Vu et al (1991) Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 64 1057. PMID: 1672265.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Thrombin Receptor Agonist Peptide include:

Tripathi et al (2014) Protease-activated receptor 2 (PAR2) is upregulated by Acanthamoeba plasminogen activator (aPA) and induces proinflammatory cytokine in human corneal epithelial cells. Invest Ophthalmol Vis Sci 55 3912. PMID: 24876278.

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Keywords: Thrombin Receptor Agonist Peptide, supplier, Causes, platelet, aggregation, secretion, PAR, Receptors, Protease-Activated, thrombin, receptor, agonists, Tocris Bioscience, Protease-Activated Receptor Agonist products

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