Thrombin Receptor Agonist Peptide
Cat. No. 1185
Alternative Name: TRAP
Biological ActivityAgonist at the thrombin receptor; causes platelet aggregation (EC50 = 4 μM) and secretion.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Vassallo et al (1992) Structure-function relationships in the activation of platelet thrombin receptors by receptor-derived peptides. J.Biol.Chem. 267 6081. PMID: 1313429.
Huang et al (1991) 'Thrombin' receptor-directed ligand accounts for activation by thrombin of platelet phospholipase C and accumulation of 3-phosphorylated phosphoinositides. J.Biol.Chem. 266 18435. PMID: 1655750.
Vu et al (1991) Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 64 1057. PMID: 1672265.
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Citations are publications that use Tocris products. Selected citations for Thrombin Receptor Agonist Peptide include:
White et al (2015) A brief exposure to tryptase or thrombin potentiates fibrocyte differentiation in the presence of serum or serum amyloid p. J Endocrinol 194 142. PMID: 25429068.
Tripathi et al (2014) Protease-activated receptor 2 (PAR2) is upregulated by Acanthamoeba plasminogen activator (aPA) and induces proinflammatory cytokine in human corneal epithelial cells. Invest Ophthalmol Vis Sci 55 3912. PMID: 24876278.
Do you know of a great paper that uses Thrombin Receptor Agonist Peptide from Tocris? If so please let us know.
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Keywords: Thrombin Receptor Agonist Peptide, supplier, Causes, platelet, aggregation, secretion, PAR, Receptors, Protease-Activated, thrombin, receptor, agonists, Tocris Bioscience, Protease-Activated Receptor Agonist products
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