α-helical CRF 9-41
Cat. No. 1184
Alternative Name: α-helical-Corticotropin-Releasing Factor 9-41
Biological ActivityCorticotropin-releasing factor receptor antagonist (Ki values are 17, 5 and 0.97 at human CRF1, rat CRF2α and mouse CRF2β receptors respectively).
Licensing InformationSold with the permission of the SALK Institute
(Modifications: Ala-33 = C-terminal amide)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Perrin and Vale (1999) Corticotropin releasing factor receptors and their ligand family. Ann.N.Y.Acad.Sci. 885 312. PMID: 10816663.
Kask et al (1997) Alpha-helical(9-41) revents anxiogenic-like effect of NPY Y1 receptor antagonist BIBP3226. NeuroReport 8 3645. PMID: 9427342.
Swerdlow et al (1989) Potentiation of acoustic startle by corticotropin-releasing factor (CRF) and by fear are both reversed by α-helical CRF (9-41). Neuropsychopharmacology 2 285. PMID: 2610824.
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Citations are publications that use Tocris products. Selected citations for α-helical CRF 9-41 include:
Jia et al (2013) Role of nesfatin-1 in a rat model of visceral hypersensitivity. J Immunol 19 3487. PMID: 23801843.
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April 1 - 5, 2017
Washington, D.C., USA