Naltrindole hydrochloride

Cat. No. 0740

Naltrindole hydrochloride C26H26N2O3.HCl [111469-81-9]

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Chemical Name: 17-(Cyclopropylmethyl)-6,7-dehydro-4,5α-epoxy-3,14-dihydroxy-6,7-2',3'-indolomorphinan hydrochloride

Biological Activity

Highly selective non-peptide δ opioid antagonist, showing 223- and 346-fold greater activity at δ than at μ  and κ opioid receptors.

Licensing Information

Sold with the permission of the University of Minnesota.

Technical Data

M.Wt:
450.96
Formula:
C26H26N2O3.HCl
Solubility:
Soluble to 25 mM in water and to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
111469-81-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Shippenberg and Heidbreder (1995) The δ-opioid receptor antagonist naltrindole prevents sensitization to the conditioned rewarding effects of cocaine. Eur.J.Pharmacol. 280 55. PMID: 7498254.

Ossipov et al (1994) Naltrindole, an opioid δ antagonist, blocks the enhancement of morphine-antinociception induced by a CCKB antagonist in the rat. Neurosci. Lett. 181 9. PMID: 7898778.

Portoghese et al (1990) Design of peptidomimetic δ opioid receptor antagonists using the message-address concept. J.Med.Chem. 33 1714. PMID: 2160538.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Naltrindole hydrochloride include:

Bigliardi et al (2015) Activation of the δ-opioid receptor promotes cutaneous wound healing by affecting keratinocyte intercellular adhesion and migration. PLoS One 172 501. PMID: 24628261.

Chen et al (2015) Berberine Improves Intestinal Motility and Visceral Pain in the Mouse Models Mimicking Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) Symptoms in an Opioid-Receptor Dependent Manner. J Neurosci 10 e0145556. PMID: 26700862.

Schuster et al (2015) Ligand requirements for involvement of PKCη in synergistic analgesic interactions between spinal μ and δ opioid receptors. J Biomed Sci 172 642. PMID: 24827408.

Yi et al (2015) Low-frequency electroacupuncture suppresses focal epilepsy and improves epilepsy-induced sleep disruptions. Diabetes 22 49. PMID: 26150021.

Leal et al (2013) Peripheral δ-opioid receptors attenuate the exercise pressor reflex. Br J Pharmacol 305 H1246. PMID: 23934854.

Romero-Picó et al (2013) Hypothalamic κ-opioid receptor modulates the orexigenic effect of ghrelin. Am J Physiol Heart Circ Physiol 38 1296. PMID: 23348063.

Beaudry et al (2011) Activation of spinal mu- and δ-opioid receptors potently inhibits substance P release induced by peripheral noxious stimuli. Neuropsychopharmacology 31 13068. PMID: 21917790.

Burbassi et al (2010) Alterations of CXCR4 function in μ-opioid receptor-deficient glia. Eur J Neurosci 32 1278. PMID: 20880358.

Sánchez-Blázquez et al (2010) Mu-opioid receptors transiently activate the Akt-nNOS pathway to produce sustained potentiation of PKC-mediated NMDAR-CaMKII signaling. PLoS One 5 e11278. PMID: 20585660.

Cheng et al (2009) Endogenous opiates in the nucleus tractus solitarius mediate electroacupuncture-induced sleep activities in rats. Neuropsychopharmacology 2011 159209. PMID: 19729491.

García-Fuster et al (2007) Effects of opiate drugs on Fas-associated protein with death domain (FADD) and effector caspases in the rat brain: regulation by the ERK1/2 MAP kinase pathway. Br J Pharmacol 32 399. PMID: 16482086.

Do you know of a great paper that uses Naltrindole hydrochloride from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: Naltrindole hydrochloride, supplier, δ-opioid, delta-opioid, selective, non-peptide, antagonists, DOP, Receptors, OP1, Tocris Bioscience, δ Opioid Receptor Antagonist products

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