Cat. No. 0740
Chemical Name: 17-(Cyclopropylmethyl)-6,7-dehydro-
Biological ActivityHighly selective non-peptide δ opioid antagonist, showing 223- and 346-fold greater activity at δ than at μ and κ opioid receptors.
Licensing InformationSold with the permission of the University of Minnesota.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Shippenberg and Heidbreder (1995) The δ-opioid receptor antagonist naltrindole prevents sensitization to the conditioned rewarding effects of cocaine. Eur.J.Pharmacol. 280 55. PMID: 7498254.
Ossipov et al (1994) Naltrindole, an opioid δ antagonist, blocks the enhancement of morphine-antinociception induced by a CCKB antagonist in the rat. Neurosci. Lett. 181 9. PMID: 7898778.
Portoghese et al (1990) Design of peptidomimetic δ opioid receptor antagonists using the message-address concept. J.Med.Chem. 33 1714. PMID: 2160538.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for Naltrindole hydrochloride include:
Burbassi et al (2010) Alterations of CXCR4 function in μ-opioid receptor-deficient glia. Eur J Neurosci 32 1278. PMID: 20880358.
Sánchez-Blázquez et al (2010) Mu-opioid receptors transiently activate the Akt-nNOS pathway to produce sustained potentiation of PKC-mediated NMDAR-CaMKII signaling. PLoS One 5 e11278. PMID: 20585660.
Do you know of a great paper that uses Naltrindole hydrochloride from Tocris? If so please let us know.
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Keywords: Naltrindole hydrochloride, supplier, δ-opioid, delta-opioid, selective, non-peptide, antagonists, DOP, Receptors, OP1, Tocris Bioscience, δ Opioid Receptor Antagonist products