Naltrexone hydrochloride

Cat. No. 0677

Naltrexone hydrochloride C20H23NO4.HCl [16676-29-2]

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Chemical Name: (5α)-17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydromorphinan-6-one hydrochloride

Biological Activity

Opioid antagonist.

Technical Data

Soluble to 100 mM in water
>99 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Gold et al (1982) Naltrexone, opiate addiction, and endorphins. Med.Res.Rev. 2 211. PMID: 6289026.

Tempel et al (1982) Supersensitivity of brain opiate receptor subtypes after chronic naltrexone treatment. Life Sci. 31 1401. PMID: 6292636.

Zukin et al (1982) Naltrexone-induced opiate receptor supersensitivity. Brain Res. 245 285. PMID: 6289965.

If you know of a relevant reference for Naltrexone hydrochloride please let us know.

Citations are publications that use Tocris products. Selected citations for Naltrexone hydrochloride include:

Leskelä et al (2012) Cys-27 variant of human δ-opioid receptor modulates maturation and cell surface delivery of Phe-27 variant via heteromerization. J Biol Chem 287 5008. PMID: 22184124.

Chung et al (2010) Hyperbaric oxygen treatment induces a 2-phase antinociceptive response of unusually long duration in mice. Hum Mol Genet 11 847. PMID: 20418186.

Jones et al (2010) Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis. Biochem Pharmacol 80 1478. PMID: 20696141.

Tumati et al (2009) Sustained morphine treatment augments capsaicin-evoked calcitonin gene-related peptide release from primary sensory neurons in a protein kinase A- and Raf-1-dependent manner. J Pain 330 810. PMID: 19491327.

Markkanen and Petäjä-Repo (2008) N-glycan-mediated quality control in the endoplasmic reticulum is required for the expression of correctly folded delta-opioid receptors at the cell surface. J Biol Chem 283 29086. PMID: 18703511.

Do you know of a great paper that uses Naltrexone hydrochloride from Tocris? If so please let us all ▼show less ▲

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Keywords: Naltrexone hydrochloride, supplier, Broad, spectrum, antagonists, Opioids, Receptors, Tocris Bioscience, Miscellaneous Opioid Antagonist products

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