Naloxone hydrochloride

Cat. No. 0599

Naloxone hydrochloride C19H21NO4.HCl [357-08-4]

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Chemical Name: (5α)-4,5-Epoxy-3,14-dihydro-17-(2-propenyl)morphinan-6-one hydrochloride

Biological Activity

Opioid antagonist.

Technical Data

M.Wt:
363.84
Formula:
C19H21NO4.HCl
Solubility:
Soluble to 100 mM in water
Purity:
>99 %
Storage:
Store at RT
CAS No:
357-08-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

Pinelli and Trivulzio (1997) Quantitative evaluation of opioid withdrawal signs in rats repeatedly treated with morphine and injected with naloxone, in the absence or presence of the antiabstinence agent clonidine. J.Pharmacol.Toxicol.Methods 38 117. PMID: 9523765.

Spivak et al (1997) Naloxone activation of mu-opioid receptors mutated at a histidine residue lining the opioid cavity. Mol.Pharmacol. 52 983. PMID: 9415708.

Olson et al (1996) Endogenous opiates: 1995. Peptides 17 1421.

Merck Index 12 6449.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Naloxone hydrochloride include:

Gerhold et al (2015) Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude. J Neurosci 35 9580. PMID: 26134641.

Liu et al (2015) Morphological and physiological evidence of a synaptic connection between the lateral parabrachial nucleus and neurons in the A7 catecholamine cell group in rats. J Biomed Sci 22 79. PMID: 26385355.

Moser and Giesler (2013) Itch and analgesia resulting from intrathecal application of morphine: contrasting effects on different populations of trigeminothalamic tract neurons. J Neurosci 33 6093. PMID: 23554490.

Zhou et al (2013) Development of functionally selective, small molecule agonists at kappa opioid receptors. J Biol Chem 288 36703. PMID: 24187130.

Ali (2011) CB1 modulation of temporally distinct synaptic facilitation among local circuit interneurons mediated by N-type calcium channels in CA1. J Neurophysiol 105 1051. PMID: 21123660.

Largent-Milnes et al (2010) Spinal or systemic TY005, a peptidic opioid agonist/neurokinin 1 antagonist, attenuates pain with reduced tolerance. Br J Pharmacol 161 986. PMID: 20977451.

Cruz et al (2008) Absence and rescue of morphine withdrawal in GIRK/Kir3 knock-out mice. J Neurosci 28 4069. PMID: 18400906.

Proudfoot et al (2006) Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain. Curr Biol 16 1591. PMID: 16920620.

Melyan et al (2004) Metabotropic regulation of intrinsic excitability by synaptic activation of kainate receptors. J Neurosci 24 4530. PMID: 15140923.

Do you know of a great paper that uses Naloxone hydrochloride from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: Naloxone hydrochloride, supplier, Broad, spectrum, opioid, antagonists, Receptors, Tocris Bioscience, Miscellaneous Opioid Antagonist products

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