Naloxone hydrochloride

Cat. No. 0599

Naloxone hydrochloride C19H21NO4.HCl [357-08-4]

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Chemical Name: (5α)-4,5-Epoxy-3,14-dihydro-17-(2-propenyl)morphinan-6-one hydrochloride

Biological Activity

Opioid antagonist.

Technical Data

Soluble to 100 mM in water
>99 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Pinelli and Trivulzio (1997) Quantitative evaluation of opioid withdrawal signs in rats repeatedly treated with morphine and injected with naloxone, in the absence or presence of the antiabstinence agent clonidine. J.Pharmacol.Toxicol.Methods 38 117. PMID: 9523765.

Spivak et al (1997) Naloxone activation of mu-opioid receptors mutated at a histidine residue lining the opioid cavity. Mol.Pharmacol. 52 983. PMID: 9415708.

Olson et al (1996) Endogenous opiates: 1995. Peptides 17 1421.

Merck Index 12 6449.

If you know of a relevant reference for Naloxone hydrochloride please let us know.

Citations are publications that use Tocris products. Selected citations for Naloxone hydrochloride include:

Chen et al (2015) Berberine Improves Intestinal Motility and Visceral Pain in the Mouse Models Mimicking Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) Symptoms in an Opioid-Receptor Dependent Manner. Psychopharmacology (Berl) 10 e0145556. PMID: 26700862.

Gerhold et al (2015) Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude. J Neurosci 35 9580. PMID: 26134641.

Kelly et al (2015) The opioid receptor pharmacology of GSK1521498 compared to other ligands with differential effects on compulsive reward-related behaviours. World J Gastroenterol 232 305. PMID: 24973897.

Koch et al (2015) Hypothalamic POMC neurons promote cannabinoid-induced feeding. J Neurosci 519 45. PMID: 25707796.

Levoye et al (2015) A Broad G Protein-Coupled Receptor Internalization Assay that Combines SNAP-Tag Labeling, Diffusion-Enhanced Resonance Energy Transfer, and a Highly Emissive Terbium Cryptate. PLoS One 6 167. PMID: 26617570.

Liu et al (2015) Morphological and physiological evidence of a synaptic connection between the lateral parabrachial nucleus and neurons in the A7 catecholamine cell group in rats. J Biomed Sci 22 79. PMID: 26385355.

Navratilova et al (2015) Endogenous opioid activity in the anterior cingulate cortex is required for relief of pain. Front Endocrinol (Lausanne) 35 7264. PMID: 25948274.

Pereira et al (2015) Endogenous Opioid-Masked Latent Pain Sensitization: Studies from Mouse to Human. Proc Natl Acad Sci U S A 10 e0134441. PMID: 26305798.

Wang et al (2015) Buprenorphine-elicited alteration of adenylate cyclase activity in human embryonic kidney 293 cells coexpressing κ-, μ-opioid and nociceptin receptors. Nature 19 2587. PMID: 26153065.

Yi et al (2015) Low-frequency electroacupuncture suppresses focal epilepsy and improves epilepsy-induced sleep disruptions. PLoS One 22 49. PMID: 26150021.

Chen et al (2014) Antinociceptive effects of novel melatonin receptor agonists in mouse models of abdominal pain. Neuropsychopharmacology 20 1298. PMID: 24574803.

Moser and Giesler (2013) Itch and analgesia resulting from intrathecal application of morphine: contrasting effects on different populations of trigeminothalamic tract neurons. J Neurosci 33 6093. PMID: 23554490.

Romero-Picó et al (2013) Hypothalamic κ-opioid receptor modulates the orexigenic effect of ghrelin. J Biomed Sci 38 1296. PMID: 23348063.

Zhou et al (2013) Development of functionally selective, small molecule agonists at kappa opioid receptors. J Biol Chem 288 36703. PMID: 24187130.

Navratilova et al (2012) Pain relief produces negative reinforcement through activation of mesolimbic reward-valuation circuitry. FASEB J 109 20709. PMID: 23184995.

Ali (2011) CB1 modulation of temporally distinct synaptic facilitation among local circuit interneurons mediated by N-type calcium channels in CA1. J Neurophysiol 105 1051. PMID: 21123660.

Largent-Milnes et al (2010) Spinal or systemic TY005, a peptidic opioid agonist/neurokinin 1 antagonist, attenuates pain with reduced tolerance. Br J Pharmacol 161 986. PMID: 20977451.

Cheng et al (2009) Endogenous opiates in the nucleus tractus solitarius mediate electroacupuncture-induced sleep activities in rats. Proc Natl Acad Sci U S A 2011 159209. PMID: 19729491.

Cruz et al (2008) Absence and rescue of morphine withdrawal in GIRK/Kir3 knock-out mice. J Neurosci 28 4069. PMID: 18400906.

García-Fuster et al (2007) Effects of opiate drugs on Fas-associated protein with death domain (FADD) and effector caspases in the rat brain: regulation by the ERK1/2 MAP kinase pathway. J Cell Mol Med 32 399. PMID: 16482086.

Patel et al (2007) Mechanisms of cardiac protection from ischemia/reperfusion injury: a role for caveolae and caveolin-1. Nat Commun 21 1565. PMID: 17272740.

Proudfoot et al (2006) Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain. Curr Biol 16 1591. PMID: 16920620.

Melyan et al (2004) Metabotropic regulation of intrinsic excitability by synaptic activation of kainate receptors. J Neurosci 24 4530. PMID: 15140923.

Moore et al (2003) Adenosine gates synaptic plasticity at hippocampal mossy fiber synapses. Neuropsychopharmacology 100 14397. PMID: 14608033.

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