Cat. No. 2814
Chemical Name: 2-(4-Morpholinyl)-8-(4-aminopheny)l
Biological ActivityPI 3-Kinase inhibitor (IC50 values are 0.098, 0.183, 0.227 and 1.967 μM for p110β, p110α, p110δ and p110γ respectively) that displays higher potency than LY 294002 (Cat No. 1130). Can be immobilized onto a solid phase.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Gharbi et al (2007) Exploring the specificity of the PI3K family inhibitor LY294002. Biochem.J. 404 15. PMID: 17302559.
If you know of a relevant reference for PI 828 please let us know.
Citations are publications that use Tocris products. Selected citations for PI 828 include:
Rogers and Gahring (2015) Upregulation of Nicotinic Acetylcholine Receptor α4+β2 through a Ligand-Independent PI3Kβ Mechanism That Is Enhanced by TNFα and the Jak2/p38Mapk Pathways. J Neurosci 10 e0143319. PMID: 26619345.
Moser et al (2014) Functional kinomics identifies candidate therapeutic targets in head and neck cancer. Clin Cancer Res 20 4274. PMID: 25125259.
Grassin-Delyle et al (2013) The expression and relaxant effect of bitter taste receptors in human bronchi. Respir Res 14 134. PMID: 24266887.
Do you know of a great paper that uses PI 828 from Tocris? If so please let us know.
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Keywords: PI 828, supplier, PI, 3-kinase, inhibitors, inhibits, potent, LY, 294002, PI3K, Phosphoinositide, 3-Kinases, PI828, Tocris Bioscience, PI 3-kinase Inhibitor products
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