OSU 6162 hydrochloride

Cat. No. 2599

OSU 6162 hydrochloride C15H23NO2S.HCl [156907-84-5]

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Alternative Name: PNU 96391

Chemical Name: (3S)-3-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine hydrochloride

Biological Activity

Dopamine stabilizer; lacks high affinity for various neuroreceptors in vitro (Ki values are 447 and 1305 nM for D2 and D3 receptors respectively and > 1 μM for other targets). Exhibits high D2 receptor occupancy in vivo; highly active on dopamine synthesis and turnover. Induces stabilizing effects on psychomotor function in behavioral tests without inducing hypolocomotion or catalepsy.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M.Wt:
317.87
Formula:
C15H23NO2S.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
156907-84-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

Natesan et al (2006) The dopamine stabilizers (S)-(-)-(3-methanesulfonyl-phenyl)-1-propyl-piperidine [(-)-OSU6162] and 4-(3-methanesulfonyl-phenyl)-1-propyl-piperidine (ACR16) show high in vivo D2 receptor occupancy, antipsychotic-like efficacy, and low potential for motor side effects in the rat. J.Pharmacol.Exp.Ther. 318 810. PMID: 16648369.

Rung et al (2005) The dopaminergic stabilizers (-)-OSU6162 and ACR16 reverse (+)-MK-801-induced social withdrawal in rats. Prog.Neuro-Psychopharm.Biol.Psychiat. 29 833.

Nichols et al (2002) PNU-96391A (OSU6162) antagonizes the development of behavioural sensitization induced by dopamine agonists in a rat model for Parkinson's disease. Neuropharmacology 43 817. PMID: 12384167.

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Keywords: OSU 6162 hydrochloride, supplier, Dopamine, stabilizer, Dopaminergic, Receptors, OSU6162, hydrochloride, PNU96391, D2, receptor, Tocris Bioscience, Dopaminergic-Related products

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