Cat. No. 2596
Alternative Name: Ko 1173
Chemical Name: 1-(2,6-Dimethylphenoxy)-2-propanami
Biological ActivityUse-dependent sodium channel blocker (IC50 values are 75.3 and 23.6 μM for tonic and use-dependent block respectively). Class Ib antiarrhythmic, neuroprotective and antimyotonic agent.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Ates et al (2006) Neuroprotective effect of mexiletine in the central nervous system of diabetic rats. Mol.Cell.Biochem. 286 125. PMID: 16541198.
Bellis et al (2006) Evaluation of the pharmacological activity of the major mexiletine metabolites on skeletal muscle sodium currents. Br.J.Pharmacol. 149 300. PMID: 16921388.
Franchini et al (2003) Optically active mexiletine analogues as stereoselective blockers of voltage-gated Na+ channels. J.Med.Chem. 46 5238. PMID: 14613326.
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Citations are publications that use Tocris products. Selected citations for Mexiletine hydrochloride include:
Rojas et al (2015) Reactive oxygen species trigger motoneuron death in non-cell-autonomous models of ALS through activation of c-Abl signaling. Front Cell Neurosci 9 203. PMID: 26106294.
Rojas et al (2014) Astrocytes expressing mutant SOD1 and TDP43 trigger motoneuron death that is mediated via sodium channels and nitroxidative stress. Front Cell Neurosci 8 24. PMID: 24570655.
Do you know of a great paper that uses Mexiletine hydrochloride from Tocris? If so please let us know.
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Keywords: Mexiletine hydrochloride, supplier, Na+, channel, blockers, antiarrhythmic, agent, Sodium, NaV, Channels, voltage-gated, voltage-dependent, Ko1173, Tocris Bioscience, Voltage-gated Sodium (NaV) Channel Blocker products
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