Mexiletine hydrochloride

Cat. No. 2596

Mexiletine hydrochloride C11H17NO.HCl [5370-01-4]

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Alternative Name: Ko 1173

Chemical Name: 1-(2,6-Dimethylphenoxy)-2-propanamine hydrochloride

Biological Activity

Use-dependent sodium channel blocker (IC50 values are 75.3 and 23.6 μM for tonic and use-dependent block respectively). Class Ib antiarrhythmic, neuroprotective and antimyotonic agent.

Technical Data

Soluble to 100 mM in water and to 100 mM in DMSO
>99 %
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Ates et al (2006) Neuroprotective effect of mexiletine in the central nervous system of diabetic rats. Mol.Cell.Biochem. 286 125. PMID: 16541198.

Bellis et al (2006) Evaluation of the pharmacological activity of the major mexiletine metabolites on skeletal muscle sodium currents. Br.J.Pharmacol. 149 300. PMID: 16921388.

Franchini et al (2003) Optically active mexiletine analogues as stereoselective blockers of voltage-gated Na+ channels. J.Med.Chem. 46 5238. PMID: 14613326.

If you know of a relevant reference for Mexiletine hydrochloride please let us know.

Citations are publications that use Tocris products. Selected citations for Mexiletine hydrochloride include:

Rojas et al (2015) Reactive oxygen species trigger motoneuron death in non-cell-autonomous models of ALS through activation of c-Abl signaling. Front Cell Neurosci 9 203. PMID: 26106294.

Rojas et al (2014) Astrocytes expressing mutant SOD1 and TDP43 trigger motoneuron death that is mediated via sodium channels and nitroxidative stress. Front Cell Neurosci 8 24. PMID: 24570655.

Do you know of a great paper that uses Mexiletine hydrochloride from Tocris? If so please let us know.

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Keywords: Mexiletine hydrochloride, supplier, Na+, channel, blockers, antiarrhythmic, agent, Sodium, NaV, Channels, voltage-gated, voltage-dependent, Ko1173, Tocris Bioscience, Voltage-gated Sodium (NaV) Channel Blocker products

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