Cat. No. 1190
Biological ActivityIrreversible inhibitor of aspartic proteases. Inhibits lysosomal proteases and interferes with autolysosomal digestion when used in combination with E 64d (Cat. No. 4545).
(Modifications: Val-1 = N-terminal H-iso-Valeryl, Val-2 = Val-4-amino-3-hydroxy-6-methyl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Sato et al (2007) Autophagy is activated in colorectal cancer cells and contributes to the tolerance to nutrient deprivation. Cancer Res. 67 9677. PMID: 17942897.
Marciniszyn et al (1976) Mode of inhibition of acid proteases by pepstatin. J.Biol.Chem. 251 7088. PMID: 993206.
Merck Index 12 7290.
If you know of a relevant reference for Pepstatin A please let us know.
Citations are publications that use Tocris products. Selected citations for Pepstatin A include:
Tsai et al (2013) WWOX suppresses autophagy for inducing apoptosis in methotrexate-treated human squamous cell carcinoma. J Neurosci 4 e792. PMID: 24008736.
Do you know of a great paper that uses Pepstatin A from Tocris? If so please let us know.
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Keywords: Pepstatin A, supplier, Aspartic, protease, inhibitors, inhibits, Proteases, Proteinases, PepstatinA, Tocris Bioscience, Other Protease Inhibitor products
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