MY-5445

Cat. No. 0432

MY-5445
 C20H14ClN3 [78351-75-4]

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Chemical Name: 1-(3-Chlorophenylamino)-4-phenylphthalazine

Biological Activity

Specific inhibitor of cyclic GMP phosphodiesterase, selective for PDE5 (IC50 = 0.5 μM).

Technical Data

M.Wt:
331.8
Formula:
C20H14ClN3
Solubility:
Soluble to 50 mM in DMSO and to 5 mM in ethanol
Storage:
Store at RT
CAS No:
78351-75-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Hagiwara et al (1984) Effect of 1-(3-chloroanilino)-4-phenylphthalazine (MY-5445), a specific inhibitor of cyclic GMP phosphodiesterase, on human platelet aggregation. J.Pharmacol.Exp.Ther. 228 467. PMID: 6141286.

Hidaka and Endo et al (1984) Selective inhibitors of three forms of cyclic nucleotide phosphodiesterase, basic and potential clinical applications. Adv.Cyclic Nucleotide Protein Phosphorylation Res. 16 245. PMID: 6144253.

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Citations are publications that use Tocris products.

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Keywords: MY-5445, supplier, PDE5, inhibitors, inhibits, PDE, Phosphodiesterases, MY, 5445, Tocris Bioscience, Phosphodiesterase Inhibitor products

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