Cat. No. 2592

TCB-2 C11H14BrNO2.HBr [912342-28-0]

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Chemical Name: (4-Bromo-3,6-dimethoxybenzocyclobuten-1-yl)methylamine hydrobromide

Biological Activity

High affinity 5-HT2A receptor agonist (Ki values are 0.73 and 0.75 nM for rat and human receptors respectively). Potently stimulates IP3 accumulation in NIH3T3 cells stably expressing rat 5-HT2A receptors (EC50 = 36 nM). Induces head twitches and hypothermia in mice following i.p. adminitration.

Technical Data

Soluble to 25 mM in water and to 100 mM in DMSO
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Niebert et al (2011) Expression and function of serotonin 2A and 2B receptors in the mammalian respiratory network. PLoS One 6 e21395. PMID: 21789169.

Fox et al (2010) The serotonin 5-HT2A receptor agonist TCB-2: a behavioral and neurophysiological analysis. Psychopharmacology 212 13. PMID: 19823806.

McLean et al (2006) 1-Aminomethylbenzocycloalkanes: conformationally restricted hallucinogenic phenethylamine analogues as functionally selective 5-HT2A receptor agonists. J.Med.Chem. 49 5794. PMID: 16970404.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for TCB-2 include:

Gerhold et al (2015) Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude. J Neurosci 35 9580. PMID: 26134641.

Watts et al (2015) 5-HT is a potent relaxant in rat superior mesenteric veins. PLoS One 3 e00103. PMID: 25692021.

Goda et al (2013) Serotonergic hallucinogens differentially modify gamma and high frequency oscillations in the rat nucleus accumbens. Psychopharmacology (Berl) 228 271. PMID: 23525524.

Niebert et al (2011) Expression and function of serotonin 2A and 2B receptors in the mammalian respiratory network. EMBO Mol Med 6 e21395. PMID: 21789169.

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Keywords: TCB-2, supplier, Potent, high, affinity, 5-HT2A, agonists, Serotonin, Receptors, Tocris Bioscience, 5-HT2A Receptor Agonist products

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