Cat. No. 2591
Chemical Name: 2-[(3,4-Dimethoxybenzoyl)amino]-4,5
Biological ActivityPotent inhibitor of FLT3 receptor tyrosine kinase (IC50 = 42 nM) that displays selectivity over a range of other kinases. Exhibits antiproliferative effects on MV4-11 cells, a human acute myelogenous leukemia cell line expressing a constitutively active mutant FLT3 (IC50 = 340 nM).
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Certificate of Analysis / Product Datasheet / Safety Data Sheet
Patch et al (2006) Identification of 2-acylaminothiophene-3-carboxamides as potent inhibitors of FLT3. Bioorg.Med.Chem.Lett. 16 3282. PMID: 16580199.
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Keywords: TCS 359, supplier, Potent, FLT3, inhibitors, inhibits, RTKs, Receptor, Tyrosine, Kinases, TCS359, Tocris Bioscience, FLT3 Inhibitor products
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