CP 465022 hydrochloride
Cat. No. 2932
Chemical Name: 3-(2-Chlorophenyl)-2-[2-[6-[(diethy
Biological ActivitySelective, non-competitive AMPA antagonist (IC50 = 25 nM in rat cortical neurons) that displays potent anticonvulsant activity. Also significantly blocks the persistent component of Nav1.6 channel activity. Brain penetrant and orally active.
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Certificate of Analysis / Product Datasheet / Safety Data Sheet
Welch et al (2008) Traditional AMPA receptor antagonists partially block Nav1.6-mediated persistent current. Neuropharmacology 55 1165. PMID: 18687344.
Menniti et al (2003) CP-465,022, a selective noncompetitive AMPA receptor antagonist, blocks AMPA receptors but is not neuroprotective in vivo. Stroke 34 171. PMID: 12511770.
Lazaro et al (2002) Functional characterization of CP-465,022, a selective, noncompetitive AMPA receptor antagonist. Neuropharmacology 42 143. PMID: 11804610.
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