CP 465022 hydrochloride

Cat. No. 2932

CP 465022 hydrochloride C26H24ClFN4O.HCl [199655-36-2]

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Chemical Name: 3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinone hydrochloride

Biological Activity

Selective, non-competitive AMPA antagonist (IC50 = 25 nM in rat cortical neurons) that displays potent anticonvulsant activity. Also significantly blocks the persistent component of Nav1.6 channel activity. Brain penetrant and orally active.

Technical Data

M.Wt:
499.41
Formula:
C26H24ClFN4O.HCl
Solubility:
Soluble to 10 mM in water and to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
199655-36-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

Welch et al (2008) Traditional AMPA receptor antagonists partially block Nav1.6-mediated persistent current. Neuropharmacology 55 1165. PMID: 18687344.

Menniti et al (2003) CP-465,022, a selective noncompetitive AMPA receptor antagonist, blocks AMPA receptors but is not neuroprotective in vivo. Stroke 34 171. PMID: 12511770.

Lazaro et al (2002) Functional characterization of CP-465,022, a selective, noncompetitive AMPA receptor antagonist. Neuropharmacology 42 143. PMID: 11804610.

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Keywords: CP 465022 hydrochloride, supplier, Selective, non-competitive, AMPA, antagonists, Glutamate, Receptors, iGluR, Ionotropic, CP465022, hydrochloride, Tocris Bioscience, AMPA Receptor Antagonist products

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