Cat. No. 2585
Biological ActivityComplement inhibitor; binds C3 inhibiting proteolytic cleavage by C3 convertase (IC50 = 28 μM) and activation of classical and alternative complement pathways (IC50 values are 63 and 12 μM respectively). Prolongs graft survival and reduces hyperacute rejection of ex vivo pig kidneys perfused with human blood and inhibits in vivo heparin/protamine-induced complement activation in baboons. Control peptide available (Cat. No. 3796).
(Modifications: Thr-13 = C-terminal amide, Disulfide bridge between 2 - 12)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Soulika et al (2000) Inhibition of heparin/protamine complex-induced complement activation by compstatin in baboons. Clin.Immunol. 96 212. PMID: 10964539.
Fiane et al (1999) Compstatin, a peptide inhibitor of C3, prolongs survival of ex vivo perfused pig xenografts. Xenotransplantation 6 52. PMID: 10355733.
Sahu et al (1996) Inhibition of human complement by a C3-binding peptide isolated from a phage-displayed random peptide library. J.Immunol. 157 884. PMID: 8752942.
If you know of a relevant reference for Compstatin please let us know.
Citations are publications that use Tocris products. Selected citations for Compstatin include:
Lee et al (2014) Mesenchymal stem cells infected with Mycoplasma arginini secrete complement C3 to regulate immunoglobulin production in b lymphocytes. Cell Death Dis 5 e1192. PMID: 24763049.
Magge et al (2013) Inhibitors of C5 complement enhance vaccinia virus oncolysis. Cancer Gene Ther 20 342. PMID: 23661042.
Sun et al (2012) Is asthma related to choroidal neovascularization? Pharmacol Res Perspect 7 e35415. PMID: 22567103.
Do you know of a great paper that uses Compstatin from Tocris? If so please let us know.
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Keywords: Compstatin, supplier, C3-binding, protein, inhibits, inhibitors, complement, activation, Convertase, Tocris Bioscience, Complement products