Compstatin

Cat. No. 2585

Compstatin Ile-Cys-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-Cys-Thr-NH2 (Disulfide bridge: 2 -12)

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Biological Activity

Complement inhibitor; binds C3 inhibiting proteolytic cleavage by C3 convertase (IC50 = 28 μM) and activation of classical and alternative complement pathways (IC50 values are 63 and 12 μM respectively). Prolongs graft survival and reduces hyperacute rejection of ex vivo pig kidneys perfused with human blood and inhibits in vivo heparin/protamine-induced complement activation in baboons. Control peptide available (Cat. No. 3796).

Technical Data

M.Wt:
1550.77
Formula:
C66H99N23O17S2
Sequence:
ICVVQDWGHHRCT

(Modifications: Thr-13 = C-terminal amide, Disulfide bridge between 2 - 12)

Solubility:
Soluble to 2 mg/ml in water
Storage:
Store at -20°C
CAS No:
206645-99-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Soulika et al (2000) Inhibition of heparin/protamine complex-induced complement activation by compstatin in baboons. Clin.Immunol. 96 212. PMID: 10964539.

Fiane et al (1999) Compstatin, a peptide inhibitor of C3, prolongs survival of ex vivo perfused pig xenografts. Xenotransplantation 6 52. PMID: 10355733.

Sahu et al (1996) Inhibition of human complement by a C3-binding peptide isolated from a phage-displayed random peptide library. J.Immunol. 157 884. PMID: 8752942.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Compstatin include:

Lee et al (2014) Mesenchymal stem cells infected with Mycoplasma arginini secrete complement C3 to regulate immunoglobulin production in b lymphocytes. Cell Death Dis 5 e1192. PMID: 24763049.

Magge et al (2013) Inhibitors of C5 complement enhance vaccinia virus oncolysis. Cancer Gene Ther 20 342. PMID: 23661042.

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Keywords: Compstatin, supplier, C3-binding, protein, inhibits, inhibitors, complement, activation, Convertase, Tocris Bioscience, Complement products

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